Literature DB >> 24417947

Adiponectin effects on the kidney.

Natalie Sweiss1, Kumar Sharma2.   

Abstract

Adiponectin is a 30-kDa polypeptide secreted primarily by adipose tissue and plays a key role in kidney disease. In obesity, reduced adiponectin levels are associated with insulin resistance, cardiovascular disease and obesity related kidney disease. The latter includes microalbuminuria, glomerulomegaly, overt proteinuria and focal segmental glomerulosclerosis. Adiponectin levels in type 2 diabetics also negatively correlate with early features of nephropathy. However, in patients with established chronic kidney disease, adiponectin levels are elevated and positively predict progression of disease. The mechanism of action of adiponectin in the kidney appears to be related to AMPK activation and NADPH oxidase. Further studies are needed to elucidate this pathway and investigate the role of potential targets of adiponectin-AMPK-Nox pathway for CKD as obesity-related CKD is increasing worldwide.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AMP-activated protein kinase; adipokines; adiponectin; albuminuria; kidney disease; obesity; oxidant stress; proteinuria

Mesh：

Substances：

Year:  2013        PMID： 24417947      PMCID： PMC4252567          DOI： 10.1016/j.beem.2013.08.002

Source DB:  PubMed          Journal:  Best Pract Res Clin Endocrinol Metab        ISSN： 1521-690X            Impact factor:   4.690


  45 in total

1.  Differential effect of baseline adiponectin on all-cause mortality in hemodialysis patients depending on initial body mass index. Long-term follow-up data of 4.5 years.

Authors:  Christina Tsigalou; Georgios Chalikias; Konstantina Kantartzi; Dimitrios Tziakas; Georgia Kampouromiti; Vassilis Vargemezis; Stavros Konstantinides; Sofia Ktenidou-Kartali; Konstantinos Simopoulos; Ploumis Passadakis
Journal:  J Ren Nutr       Date:  2012-03-09       Impact factor: 3.655

Review 2.  The adipose tissue as an endocrine organ.

Authors:  Marcin Adamczak; Andrzej Wiecek
Journal:  Semin Nephrol       Date:  2013-01       Impact factor: 5.299

3.  Plasma adiponectin before and after kidney transplantation.

Authors:  Thomas Idorn; Mads Hornum; Mette Bjerre; Kaj Anker Jørgensen; Finn Thomsen Nielsen; Jesper Melchior Hansen; Allan Flyvbjerg; Bo Feldt-Rasmussen
Journal:  Transpl Int       Date:  2012-09-21       Impact factor: 3.782

4.  A central body fat distribution is related to renal function impairment, even in lean subjects.

Authors:  Sara-Joan Pinto-Sietsma; Gerjan Navis; Wilbert M T Janssen; Dick de Zeeuw; Reinhold O B Gans; Paul E de Jong
Journal:  Am J Kidney Dis       Date:  2003-04       Impact factor: 8.860

5.  Adiponectin in essential hypertension.

Authors:  Francesca Mallamaci; Carmine Zoccali; Fortunata Cuzzola; Giovanni Tripepi; Sebastiano Cutrupi; Saverio Parlongo; Sachiyo Tanaka; Noriyuki Ouchi; Shinji Kihara; Tohru Funahashi; Yuji Matsuzawa
Journal:  J Nephrol       Date:  2002 Sep-Oct       Impact factor: 3.902

6.  Association of 276G>T adiponectin gene polymorphism to plasma adiponectin and albuminuria in type 2 diabetic patients.

Authors:  Ina Maria Kacso; Adrian Pavel Trifa; Radu Anghel Popp; Gabriel Kacso
Journal:  Int Urol Nephrol       Date:  2012-01-06       Impact factor: 2.370

7.  Plasma adiponectin is related to the progression of kidney disease in type 2 diabetes patients.

Authors:  Ina Maria Kacso; Cosmina Ioana Bondor; Gabriel Kacso
Journal:  Scand J Clin Lab Invest       Date:  2012-04-10       Impact factor: 1.713

8.  Low plasma adiponectin levels predict increased urinary albumin/creatinine ratio in type 2 diabetes patients.

Authors:  I Kacso; A Lenghel; C I Bondor; D Moldovan; C Rusu; C Nita; N Hancu; M Gherman Caprioara; G Kacso
Journal:  Int Urol Nephrol       Date:  2011-10-13       Impact factor: 2.370

9.  Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.

Authors:  Katherine M Flegal; Margaret D Carroll; Brian K Kit; Cynthia L Ogden
Journal:  JAMA       Date:  2012-01-17       Impact factor: 56.272

10.  Adiponectin promotes functional recovery after podocyte ablation.

Authors:  Joseph M Rutkowski; Zhao V Wang; Ae Seo Deok Park; Jianning Zhang; Dihua Zhang; Ming Chang Hu; Orson W Moe; Katalin Susztak; Philipp E Scherer
Journal:  J Am Soc Nephrol       Date:  2013-01-18       Impact factor: 10.121
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  16 in total

Review 1.  Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.

Authors:  Jennifer H Stern; Joseph M Rutkowski; Philipp E Scherer
Journal:  Cell Metab       Date:  2016-05-10       Impact factor: 27.287

2.  Relationship of adiponectin to markers of oxidative stress in type 2 diabetic patients: influence of incipient diabetes-associated kidney disease.

Authors:  Cosmina Ioana Bondor; Alina Ramona Potra; Diana Moldovan; Crina Claudia Rusu; Mariana Ciorba Pop; Adriana Muresan; Dan Stefan Vladutiu; Ina Maria Kacso
Journal:  Int Urol Nephrol       Date:  2015-05-14       Impact factor: 2.370

3.  Effects of diet and exercise on adipocytokine levels in patients with moderate to severe chronic kidney disease.

Authors:  Nihal Aydemir; Mindy M Pike; Aseel Alsouqi; Samuel A E Headley; Katherine Tuttle; Elizabeth E Evans; Charles M Milch; Kelsey A Moody; Michael Germain; Loren Lipworth; Jonathan Himmelfarb; T A Ikizler; Cassianne Robinson-Cohen
Journal:  Nutr Metab Cardiovasc Dis       Date:  2020-04-21       Impact factor: 4.222

4.  Albuminuria is associated with elevated acute phase reactants and proinflammatory markers in HIV-infected patients receiving suppressive combination antiretroviral therapy.

Authors:  Pichaya O-charoen; Lishomwa C Ndhlovu; Louie Mar A Gangcuangco; Sheila M Keating; Philip J Norris; Roland C K Ng; Brooks I Mitchell; Cecilia M Shikuma; Dominic C Chow
Journal:  AIDS Res Hum Retroviruses       Date:  2014-12       Impact factor: 2.205

5.  Protective effects of berberine on high fat-induced kidney damage by increasing serum adiponectin and promoting insulin sensitivity.

Authors:  Ueyue Wu; Ying Cha; Xinmei Huang; Jun Liu; Zaoping Chen; Fang Wang; Jiong Xu; Li Sheng; Heyuan Ding
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

6.  Association of Plasma Adiponectin and Oxidized Low-Density Lipoprotein with Carotid Intima-Media Thickness in Diabetic Nephropathy.

Authors:  Anna Tavridou; Anastasia Georgoulidou; Athanasios Roumeliotis; Stefanos Roumeliotis; Efstathia Giannakopoulou; Nikolaos Papanas; Ploumis Passadakis; Vangelis G Manolopoulos; Vassilis Vargemezis
Journal:  J Diabetes Res       Date:  2015-05-12       Impact factor: 4.011

7.  Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes.

Authors:  Lorena Ortega Moreno; Olga Lamacchia; Massimiliano Copetti; Lucia Salvemini; Concetta De Bonis; Salvatore De Cosmo; Mauro Cignarelli; Vincenzo Trischitta; Claudia Menzaghi
Journal:  PLoS One       Date:  2015-10-14       Impact factor: 3.240

8.  Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway.

Authors:  Xiaohong Xu; Xiaolin Huang; Liexiang Zhang; Xiaoli Huang; Zihan Qin; Fei Hua
Journal:  BMC Nephrol       Date:  2021-06-10       Impact factor: 2.388

9.  Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease.

Authors:  Ji Hye Kim; Ji Min Han; Hyang Kim; Kyu-Beck Lee; Wookyung Chung; Yong-Soo Kim; Sue K Park; Dong Wan Chae; Curie Ahn; Kook-Hwan Oh; Young Youl Hyun
Journal:  Sci Rep       Date:  2021-05-25       Impact factor: 4.379

10.  Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy.

Authors:  Hoon Suk Park; Ji Hee Lim; Min Young Kim; Yaeni Kim; You Ah Hong; Sun Ryoung Choi; Sungjin Chung; Hyung Wook Kim; Bum Soon Choi; Yong Soo Kim; Yoon Sik Chang; Cheol Whee Park
Journal:  J Transl Med       Date:  2016-06-11       Impact factor: 5.531
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