Ronald J Wong1, Stephanie Schulz, Cecilia Espadas, Hendrik J Vreman, Jayakumar Rajadas, David K Stevenson.
Abstract
UNLABELLED: Zinc protoporphyrin (ZnPP) is a promising metalloporphyrin with sufficient potency, but has poor solubility and is not absorbed well orally. Intragastric administration of ZnPP microparticles (30 μmol/kg) to 3-day-old mice resulted in a twofold increase in potency and no signs of phototoxicity.
CONCLUSION: The use of polymeric particulate delivery systems can improve the stability and enhance intestinal absorption of ZnPP, while retaining HO inhibitory potency without photosensitising effects, and thus is potentially useful in treating neonatal hyperbilirubinemia. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
UNLABELLED: Zinc protoporphyrin (ZnPP) is a promising metalloporphyrin with sufficient potency, but has poor solubility and is not absorbed well orally. Intragastric administration of ZnPP microparticles (30 μmol/kg) to 3-day-old mice resulted in a twofold increase in potency and no signs of phototoxicity.
CONCLUSION: The use of polymeric particulate delivery systems can improve the stability and enhance intestinal absorption of ZnPP, while retaining HO inhibitory potency without photosensitising effects, and thus is potentially useful in treating neonatal hyperbilirubinemia. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Entities:
Keywords:
Bilirubin; Heme oxygenase; Metalloporphyrin; Neonatal jaundice; Phototoxicity
Mesh：
Substances：
Year: 2014
PMID： 24417721 DOI： 10.1111/apa.12554
Source DB: PubMed Journal: Acta Paediatr ISSN： 0803-5253 Impact factor: 2.299