Zaneta Wareńczak-Florczak1, Andrzej Roszak2, Krystyna Bratos1, Piotr Milecki3, Aldona Karczewska-Dzionk4, Hanna Włodarczyk1. 1. Greater Poland Cancer Centre, Department of Gynaecological Radiotherapy and Oncology, Garbary Street 15, 61-866 Poznan, Poland. 2. Greater Poland Cancer Centre, Department of Gynaecological Radiotherapy and Oncology, Garbary Street 15, 61-866 Poznan, Poland ; Karol Marcinkowski University of Medical Sciences, Department of Electroradiology, Garbary Street 15, 61-866 Poznan, Poland. 3. Karol Marcinkowski University of Medical Sciences, Department of Electroradiology, Garbary Street 15, 61-866 Poznan, Poland ; Greater Poland Cancer Centre, Department of Radiation Oncology, Garbary Street 15, 61-866 Poznan, Poland. 4. Greater Poland Cancer Centre, Department of Radiation Oncology, Garbary Street 15, 61-866 Poznan, Poland.
Abstract
AIM: The aim of this study was to assess the therapeutic effect of intraoperative radiotherapy, describe the method, and examine the occurrence of side effects and quality of life. BACKGROUND: Breast conserving therapy has recently become a standard treatment modality in patients with early invasive cancer. Radiotherapy, along with surgery, is an integral part of such treatment. The important thing of radiotherapy is to deliver a high dose to the tumour bed. One of the methods is the intraoperative radiotherapy. MATERIALS AND METHODS: The analysis comprised sixty Tis-T2N0-1A breast cancer patients treated with breast conserving surgery. Patients' mean age was 57 years (range: 32-73 years). Intraoperative radiation therapy was delivered in the operating theatre during surgery and involved a single dose of 10 Gy with an electron beam of 4, 6, 9 or 12 MeV. After that, all patients were treated with whole breast irradiation. During one year observation photos and side effects examination were made. RESULTS: Physical and imaging examinations performed during a one-year follow-up revealed no local or distant relapse and good tolerance of IORT. Acute mild responses to the radiotherapy occurred in 23.3% of patients. Based on the examination, a good and very good cosmetic effect was found in 78.3%, with 83.3% of patients evaluating their treatment effects in the same way. CONCLUSIONS: Due to its exceptional physical and radiobiological properties, intraoperative radiation therapy can be a good alternative to other methods of boosting dose to the post-operative site in management of low stage breast cancer, enabling a precise therapy to the tumour bed.
AIM: The aim of this study was to assess the therapeutic effect of intraoperative radiotherapy, describe the method, and examine the occurrence of side effects and quality of life. BACKGROUND: Breast conserving therapy has recently become a standard treatment modality in patients with early invasive cancer. Radiotherapy, along with surgery, is an integral part of such treatment. The important thing of radiotherapy is to deliver a high dose to the tumour bed. One of the methods is the intraoperative radiotherapy. MATERIALS AND METHODS: The analysis comprised sixty Tis-T2N0-1A breast cancerpatients treated with breast conserving surgery. Patients' mean age was 57 years (range: 32-73 years). Intraoperative radiation therapy was delivered in the operating theatre during surgery and involved a single dose of 10 Gy with an electron beam of 4, 6, 9 or 12 MeV. After that, all patients were treated with whole breast irradiation. During one year observation photos and side effects examination were made. RESULTS: Physical and imaging examinations performed during a one-year follow-up revealed no local or distant relapse and good tolerance of IORT. Acute mild responses to the radiotherapy occurred in 23.3% of patients. Based on the examination, a good and very good cosmetic effect was found in 78.3%, with 83.3% of patients evaluating their treatment effects in the same way. CONCLUSIONS: Due to its exceptional physical and radiobiological properties, intraoperative radiation therapy can be a good alternative to other methods of boosting dose to the post-operative site in management of low stage breast cancer, enabling a precise therapy to the tumour bed.
Entities:
Keywords:
Breast conserving therapy; Cosmetic effect; Intraoperative therapy; Side effects
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