Lisa Richters1, Monika Ortmann2, Michael Faust3, Stefan Krämer1, Peter Mallmann1, Nadia Harbeck4, Kerstin Rhiem1. 1. Breast Center, Department of Obstetrics and Gynecology, University Hospital of Cologne, Germany. 2. Institute of Pathology, University of Cologne, Germany. 3. Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital of Cologne, Germany. 4. Breast Center, Department of Obstetrics and Gynecology, University Hospital of Cologne, Germany ; Breast Center, Department of Obstetrics and Gynecology, University Hospital of Munich, Germany.
Abstract
BACKGROUND: Paraneoplastic hypoglycemia is a rare syndrome amoung tumorous diseases. It is often associated with a paraneoplastic secretion of 'big' insulin-like growth factor-II. METHODS: We describe this syndrome in a 60-year-old patient with advanced breast cancer 8 years after primary diagnosis. RESULTS AND CONCLUSION: This non-islet cell tumor-induced hypoglycemia may be the only evidence for an otherwise clinically occult disease progression. Fast diagnosis and appropriate acute and causal treatment concepts should be part of oncological management.
BACKGROUND:Paraneoplastic hypoglycemia is a rare syndrome amoung tumorous diseases. It is often associated with a paraneoplastic secretion of 'big' insulin-like growth factor-II. METHODS: We describe this syndrome in a 60-year-old patient with advanced breast cancer 8 years after primary diagnosis. RESULTS AND CONCLUSION: This non-islet cell tumor-induced hypoglycemia may be the only evidence for an otherwise clinically occult disease progression. Fast diagnosis and appropriate acute and causal treatment concepts should be part of oncological management.
Entities:
Keywords:
Breast cancer; Hypoglycemia; Insulin-like growth factor; Metastases; Paraneoplastic
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