Literature DB >> 24414184

Cirrhosis improvement to alcoholic liver fibrosis after passive abstinence.

Hideaki Takahashi1, Ryuta Shigefuku, Shiro Maeyama, Michihiro Suzuki.   

Abstract

We present a rare case of long-term alcoholic liver disease that progressed from alcoholic liver fibrosis to alcoholic liver cirrhosis, and following passive abstinence, the patient's condition then improved to alcoholic liver fibrosis. A 70-year-old Japanese man who had consumed large amounts of alcohol since he was 20 years old received a liver biopsy for evaluation of liver dysfunction at the age of 48 in 1991. The biopsy indicated alcoholic liver fibrosis, stage 2. Eight years later, a second biopsy indicated alcoholic liver cirrhosis. The patient continued to drink until a cerebral haemorrhage in 2000 led to left hemiparesis. Thereafter, he had to accept passive abstinence. He then received follow-up liver biopsies in 2001 and 2002, both of which indicated improvement of the fibrosis.

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Year:  2014        PMID: 24414184      PMCID: PMC3902963          DOI: 10.1136/bcr-2013-201618

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  15 in total

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4.  Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells.

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9.  Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis.

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  2 in total

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