Literature DB >> 24414000

Suppressors of cytokine signaling (SOCS) and type 2 diabetes.

Xiaotao Feng1, Hongzhen Tang, Jing Leng, Qiuyan Jiang.   

Abstract

The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes involving regulation of the insulin signaling and pancreatic β-cell function, and that SOCS are promising to be the targets for the treatment of type 2 diabetes. In this review, we focus on the emerging role for SOCS and the potential drugs targeting SOCS for type 2 diabetes.

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Year:  2014        PMID： 24414000     DOI： 10.1007/s11033-014-3079-8

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  36 in total

1.  Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells.

Authors:  Valerio Pazienza; Manlio Vinciguerra; Angelo Andriulli; Alessandra Mangia
Journal:  J Gen Virol       Date:  2010-03-31       Impact factor: 3.891

2.  Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein.

Authors:  Junqin Chen; Francesca M Couto; Alexandra H Minn; Anath Shalev
Journal:  Biochem Biophys Res Commun       Date:  2006-06-13       Impact factor: 3.575

3.  PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.

Authors:  Ji-Ming Ye; Jennifer Tid-Ang; Nigel Turner; Xiao-Yi Zeng; Hai-Yan Li; Gregory J Cooney; Erik Max Wulff; Per Sauerberg; Edward W Kraegen
Journal:  Br J Pharmacol       Date:  2011-06       Impact factor: 8.739

4.  A meta-analysis of serious adverse events reported with exenatide and liraglutide: acute pancreatitis and cancer.

Authors:  Carlos Alves; Francisco Batel-Marques; Ana F Macedo
Journal:  Diabetes Res Clin Pract       Date:  2012-09-23       Impact factor: 5.602

5.  Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.

Authors:  Yukiko Kanatani; Isao Usui; Ken Ishizuka; Agussalim Bukhari; Shiho Fujisaka; Masaharu Urakaze; Tetsuro Haruta; Tadamitsu Kishimoto; Tetsuji Naka; Masashi Kobayashi
Journal:  Diabetes       Date:  2007-03       Impact factor: 9.461

6.  Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

Authors:  A E Karlsen; P E Heding; H Frobøse; S G Rønn; M Kruhøffer; T F Orntoft; M Darville; D L Eizirik; F Pociot; J Nerup; T Mandrup-Poulsen; N Billestrup
Journal:  Diabetologia       Date:  2004-12-02       Impact factor: 10.122

7.  Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Authors:  Mark M W Chong; Ye Chen; Rima Darwiche; Nadine L Dudek; Windy Irawaty; Pere Santamaria; Janette Allison; Thomas W H Kay; Helen E Thomas
Journal:  J Immunol       Date:  2004-05-01       Impact factor: 5.422

8.  Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis.

Authors:  Luiz F Rezende; André S Vieira; Alessandro Negro; Francesco Langone; Antonio C Boschero
Journal:  Cytokine       Date:  2009-03-09       Impact factor: 3.861

9.  Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Authors:  Ulf Risérus; Dennis Sprecher; Tony Johnson; Eric Olson; Sandra Hirschberg; Aixue Liu; Zeke Fang; Priti Hegde; Duncan Richards; Leli Sarov-Blat; Jay C Strum; Samar Basu; Jane Cheeseman; Barbara A Fielding; Sandy M Humphreys; Theodore Danoff; Niall R Moore; Peter Murgatroyd; Stephen O'Rahilly; Pauline Sutton; Tim Willson; David Hassall; Keith N Frayn; Fredrik Karpe
Journal:  Diabetes       Date:  2007-11-16       Impact factor: 9.461

10.  Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.

Authors:  Lucía Serrano-Marco; Ricardo Rodríguez-Calvo; Ilhem El Kochairi; Xavier Palomer; Liliane Michalik; Walter Wahli; Manuel Vázquez-Carrera
Journal:  Diabetes       Date:  2011-05-26       Impact factor: 9.461
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  11 in total

1.  Genome-wide association study identifies QTLs for displacement of abomasum in Chinese Holstein cattle1.

Authors:  Hetian Huang; Jie Cao; Gang Guo; Xizhi Li; Yachun Wang; Ying Yu; Shengli Zhang; Qin Zhang; Yi Zhang
Journal:  J Anim Sci       Date:  2019-03-01       Impact factor: 3.159

2.  Interleukin-13 ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke.

Authors:  Keng-Ying Liao; Chun-Jung Chen; Sheng-Kuo Hsieh; Ping-Ho Pan; Wen-Ying Chen
Journal:  Metab Brain Dis       Date:  2020-07-06       Impact factor: 3.584

Review 3.  Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells.

Authors:  Cheng Ye; John P Driver
Journal:  Front Immunol       Date:  2016-05-09       Impact factor: 7.561

4.  A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes.

Authors:  Zhihua Du; Vladimir N Uversky
Journal:  Int J Mol Sci       Date:  2017-09-21       Impact factor: 5.923

5.  Protective effects of SOCS3 overexpression in high glucose‑induced lung epithelial cell injury through the JAK2/STAT3 pathway.

Authors:  Wei-Na Duan; Zhong-Yuan Xia; Min Liu; Qian Sun; Shao-Qing Lei; Xiao-Jing Wu; Qing-Tao Meng; Yan Leng
Journal:  Mol Med Rep       Date:  2017-07-06       Impact factor: 2.952

6.  ANTI-DIABETIC EFFECTS OF ZHUODUQING FORMULA, A CHINESE HERBAL DECOCTION, ON A RAT MODEL OF TYPE 2 DIABETES.

Authors:  Xiao-Tao Feng; Shu-Yan Tang; Yun-Xia Jiang; Wei Zhao
Journal:  Afr J Tradit Complement Altern Med       Date:  2017-03-01

Review 7.  Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B.

Authors:  Zhi Yi Goh; Ee Chee Ren; Hui Ling Ko
Journal:  World J Gastroenterol       Date:  2021-04-14       Impact factor: 5.742

8.  Analysis of the frequency of single nucleotide polymorphisms in cytokine genes in patients with New Onset Diabetes After Transplant.

Authors:  Mohamed Jahromi; Torki Al-Otaibi; Osama Ashry Gheith; Nashwa Farouk Othman; Tarek Mahmoud; Parasad Nair; Medhat A-Halim; Parul Aggarwal; Grace Messenger; Philip Chu; Sacha A De Serres; Jamil R Azzi
Journal:  Sci Rep       Date:  2021-03-16       Impact factor: 4.379

9.  Revealing new candidate genes for reproductive traits in pigs: combining Bayesian GWAS and functional pathways.

Authors:  Lucas L Verardo; Fabyano F Silva; Marcos S Lopes; Ole Madsen; John W M Bastiaansen; Egbert F Knol; Mathew Kelly; Luis Varona; Paulo S Lopes; Simone E F Guimarães
Journal:  Genet Sel Evol       Date:  2016-02-01       Impact factor: 4.297

10.  Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2.

Authors:  Jiayu Li; Rong Dong; Jiali Yu; Sun Yi; Jingjing Da; Fuxun Yu; Yan Zha
Journal:  Drug Des Devel Ther       Date:  2018-09-11       Impact factor: 4.162
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