Literature DB >> 24413763

Transgenic rice endosperm as a bioreactor for molecular pharming.

Jiquan Ou1, Zhibin Guo, Jingni Shi, Xianghong Wang, Jingru Liu, Bo Shi, Fengli Guo, Chufu Zhang, Daichnag Yang.   

Abstract

Plants provide a promising expression platform for producing recombinant proteins with several advantages in terms of high expression level, lower production cost, scalability, and safety and environment-friendly. Molecular pharming has been recognized as an emerging industry with strategic importance that could play an important role in economic development and healthcare in China. Here, this review represents the significant advances using transgenic rice endosperm as bioreactor to produce various therapeutic recombinant proteins in transgenic rice endosperm and large-scale production of OsrHSA, and discusses the challenges to develop molecular pharming as an emerging industry with strategic importance in China.

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Year:  2014        PMID： 24413763     DOI： 10.1007/s00299-013-1559-2

Source DB:  PubMed          Journal:  Plant Cell Rep        ISSN： 0721-7714            Impact factor:   4.570


  50 in total

1.  The production of recombinant proteins in transgenic barley grains.

Authors:  H Horvath; J Huang; O Wong; E Kohl; T Okita; C G Kannangara; D von Wettstein
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

Review 2.  Seed-based expression systems for plant molecular farming.

Authors:  Joseph Boothe; Cory Nykiforuk; Yin Shen; Steven Zaplachinski; Steven Szarka; Philip Kuhlman; Elizabeth Murray; Douglas Morck; Maurice M Moloney
Journal:  Plant Biotechnol J       Date:  2010-06       Impact factor: 9.803

Review 3.  Advances in plant molecular farming.

Authors:  Olawole O Obembe; Jacob O Popoola; Sadhu Leelavathi; Siva V Reddy
Journal:  Biotechnol Adv       Date:  2010-11-27       Impact factor: 14.227

4.  Production of human growth hormone in transgenic rice seeds: co-introduction of RNA interference cassette for suppressing the gene expression of endogenous storage proteins.

Authors:  Takanari Shigemitsu; Shinji Ozaki; Yuhi Saito; Masaharu Kuroda; Shigeto Morita; Shigeru Satoh; Takehiro Masumura
Journal:  Plant Cell Rep       Date:  2011-11-23       Impact factor: 4.570

5.  Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease.

Authors:  Ari Zimran; Einat Brill-Almon; Raul Chertkoff; Milan Petakov; Francisco Blanco-Favela; Eduardo Terreros Muñoz; Sergio E Solorio-Meza; Dominick Amato; Gloria Duran; Fiorina Giona; Rene Heitner; Hanna Rosenbaum; Pilar Giraldo; Atul Mehta; Glen Park; Mici Phillips; Deborah Elstein; Gheona Altarescu; Mali Szleifer; Sharon Hashmueli; David Aviezer
Journal:  Blood       Date:  2011-09-06       Impact factor: 22.113

6.  Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens.

Authors:  R van Ree; M Cabanes-Macheteau; J Akkerdaas; J P Milazzo; C Loutelier-Bourhis; C Rayon; M Villalba; S Koppelman; R Aalberse; R Rodriguez; L Faye; P Lerouge
Journal:  J Biol Chem       Date:  2000-04-14       Impact factor: 5.157

7.  Low frequency of transgene flow from Bt/CpTI rice to its non-transgenic counterparts planted at close spacing.

Authors:  Jun Rong; Zhiping Song; Jun Su; Hui Xia; Bao-Rong Lu; Feng Wang
Journal:  New Phytol       Date:  2005-12       Impact factor: 10.151

8.  Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed.

Authors:  Liping Zhang; Jingni Shi; Daiming Jiang; Jacek Stupak; Jiquan Ou; Qichuan Qiu; Na An; Jianjun Li; Daichang Yang
Journal:  J Biotechnol       Date:  2013-01-31       Impact factor: 3.307

9.  Gene flow from cultivated rice (Oryza sativa) to its weedy and wild relatives.

Authors:  Li Juan Chen; Dong Sun Lee; Zhi Ping Song; Hak Soo Suh; Bao-Rong Lu
Journal:  Ann Bot       Date:  2003-11-05       Impact factor: 4.357

Review 10.  Biopharming to increase bioactive peptides in rice seed.

Authors:  Lijun Yang; Yuhya Wakasa; Fumio Takaiwa
Journal:  J AOAC Int       Date:  2008 Jul-Aug       Impact factor: 1.913
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  10 in total

1.  Non-random chromosome arrangement in triploid endosperm nuclei.

Authors:  Célia Baroux; Ales Pecinka; Jörg Fuchs; Gregor Kreth; Ingo Schubert; Ueli Grossniklaus
Journal:  Chromosoma       Date:  2016-02-19       Impact factor: 4.316

2.  Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice.

Authors:  Hartinio N Nahampun; Brad Bosworth; Joan Cunnick; Mark Mogler; Kan Wang
Journal:  Plant Cell Rep       Date:  2015-02-13       Impact factor: 4.570

3.  CRISPR/Cas9-mediated knockout of the RDR6 gene in Nicotiana benthamiana for efficient transient expression of recombinant proteins.

Authors:  Kouki Matsuo; Go Atsumi
Journal:  Planta       Date:  2019-05-07       Impact factor: 4.116

4.  Compensatory rebalancing of rice prolamins by production of recombinant prolamin/bioactive peptide fusion proteins within ER-derived protein bodies.

Authors:  Fumio Takaiwa; Lijun Yang; Yuhya Wakasa; Kenjiro Ozawa
Journal:  Plant Cell Rep       Date:  2017-10-26       Impact factor: 4.570

5.  Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy--a new mucosal vaccine formulation against Japanese cedar pollen allergy.

Authors:  Yuhya Wakasa; Hidenori Takagi; Nobumasa Watanabe; Noriko Kitamura; Yoshihiro Fujiwara; Yuko Ogo; Shimpei Hayashi; Lijun Yang; Masaru Ohta; Wai Wai Thet Tin; Kenji Sekikawa; Makoto Takano; Kenjirou Ozawa; Takachika Hiroi; Fumio Takaiwa
Journal:  PLoS One       Date:  2015-03-16       Impact factor: 3.240

6.  A double built-in containment strategy for production of recombinant proteins in transgenic rice.

Authors:  Xianwen Zhang; Dongfang Wang; Sinan Zhao; Zhicheng Shen
Journal:  PLoS One       Date:  2014-12-22       Impact factor: 3.240

7.  Assessment of the immunogenicity of residual host cell protein impurities of OsrHSA.

Authors:  Naghmeh Abiri; Jianlei Pang; Jiquan Ou; Bo Shi; Xianghong Wang; Sucai Zhang; Yunxia Sun; Daichang Yang
Journal:  PLoS One       Date:  2018-03-07       Impact factor: 3.240

8.  Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells.

Authors:  Kai Fu; Qin Cheng; Zhenwei Liu; Zhen Chen; Yan Wang; Honggang Ruan; Lu Zhou; Jie Xiong; Ruijing Xiao; Shengwu Liu; Qiuping Zhang; Daichang Yang
Journal:  PLoS One       Date:  2014-08-06       Impact factor: 3.240

9.  Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

Authors:  Evangelia Vamvaka; Elsa Arcalis; Koreen Ramessar; Abbey Evans; Barry R O'Keefe; Robin J Shattock; Vicente Medina; Eva Stöger; Paul Christou; Teresa Capell
Journal:  Plant Biotechnol J       Date:  2016-01-23       Impact factor: 9.803

Review 10.  Plants as Factories for Human Pharmaceuticals: Applications and Challenges.

Authors:  Jian Yao; Yunqi Weng; Alexia Dickey; Kevin Yueju Wang
Journal:  Int J Mol Sci       Date:  2015-12-02       Impact factor: 5.923
  10 in total

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