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Literature DB >> 24413198

PARP inhibitors and IR join forces to strike glioblastoma-initiating cells.

N Lugli¹, I Kamileri², T D Halazonetis³.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 24413198 PMCID： PMC3890962 DOI： 10.1038/cdd.2013.172

Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828

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19 in total

1. Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell.

Authors: J Smith; E Ladi; M Mayer-Proschel; M Noble
Journal: Proc Natl Acad Sci U S A Date: 2000-08-29 Impact factor: 11.205

2. Newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitors.

Authors: Marina Tsatmali; Elisabeth C Walcott; Kathryn L Crossin
Journal: Brain Res Date: 2005-04-08 Impact factor: 3.252

3. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.

Authors: Janel E Le Belle; Nicolas M Orozco; Andres A Paucar; Jonathan P Saxe; Jack Mottahedeh; April D Pyle; Hong Wu; Harley I Kornblum
Journal: Cell Stem Cell Date: 2011-01-07 Impact factor: 24.633

Review 4. Role of PARP inhibitors in cancer biology and therapy.

Authors: D Davar; J H Beumer; L Hamieh; H Tawbi
Journal: Curr Med Chem Date: 2012 Impact factor: 4.530

5. Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures.

Authors: Marina Tsatmali; Elisabeth C Walcott; Helen Makarenkova; Kathryn L Crossin
Journal: Mol Cell Neurosci Date: 2006-09-26 Impact factor: 4.314

6. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.

Authors: Keisuke Ito; Atsushi Hirao; Fumio Arai; Sahoko Matsuoka; Keiyo Takubo; Isao Hamaguchi; Kana Nomiyama; Kentaro Hosokawa; Kazuhiro Sakurada; Naomi Nakagata; Yasuo Ikeda; Tak W Mak; Toshio Suda
Journal: Nature Date: 2004-10-21 Impact factor: 49.962

PARP inhibitors and IR join forces to strike glioblastoma-initiating cells.

1. Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell.

2. Newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitors.

3. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.

Review 4. Role of PARP inhibitors in cancer biology and therapy.

5. Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures.

6. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.

7. Isolation of cancer stem cells from adult glioblastoma multiforme.

Review 8. Cellular responses to reactive oxygen species-induced DNA damage and aging.

9. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

10. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

Review 1. Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future.

2. p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression.