Literature DB >> 24413091

Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin.

Keshab Rijal1, Xun Bao, Christine S Chow.   

Abstract

Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(II) complexes were synthesized, and a reactivity study with 16S ribosomal RNA was carried out. The amino acid-linked analogues show altered specificity compared to the parental compound cisplatin.

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Year:  2014        PMID： 24413091     DOI： 10.1039/c3cc49035a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Toward multifunctional anticancer therapeutics: post-synthetic carbonate functionalisation of asymmetric Au(i) bis-N-heterocyclic carbenes.

Authors:  Sajal Sen; Mark W Perrin; Adam C Sedgwick; Evie Y Dunsky; Vincent M Lynch; Xiao-Peng He; Jonathan L Sessler; Jonathan F Arambula
Journal:  Chem Commun (Camb)       Date:  2020-06-10       Impact factor: 6.222

Review 2.  Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Authors:  Jessica L Childs-Disney; Matthew D Disney
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-22       Impact factor: 13.820

Review 3.  The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.

Authors:  Timothy C Johnstone; Kogularamanan Suntharalingam; Stephen J Lippard
Journal:  Chem Rev       Date:  2016-02-11       Impact factor: 60.622

4.  Cisplatin Targeting of Bacterial Ribosomal RNA Hairpins.

Authors:  Gayani N P Dedduwa-Mudalige; Christine S Chow
Journal:  Int J Mol Sci       Date:  2015-09-07       Impact factor: 5.923

5.  Amino acid-linked platinum(II) compounds: non-canonical nucleoside preferences and influence on glycosidic bond stabilities.

Authors:  Bett Kimutai; C C He; Andrew Roberts; Marcel L Jones; Xun Bao; Jun Jiang; Zhihua Yang; M T Rodgers; Christine S Chow
Journal:  J Biol Inorg Chem       Date:  2019-07-29       Impact factor: 3.358
  5 in total

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