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Literature DB >> 2441242

The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons.

Abstract

SS-B/La is a nuclear protein of 48 kilodaltons with two structural domains of Mr 28,000 and Mr 23,000 generated by proteolytic cleavage. UV irradiation was used to cross-link preexisting intracellular La-RNA complexes. Subsequent protease digestion and diagonal gel electrophoresis showed that the RNA-binding site resided in the nonphosphorylated, methionine-rich 28-kilodalton domain.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1987 PMID： 2441242 PMCID： PMC365394 DOI： 10.1128/mcb.7.7.2588-2591.1987

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

31 in total

1. Epitopes, structural domains, and asymmetry of amino acid residues in SS-B/La nuclear protein.

Authors: E K Chan; A M Francoeur; E M Tan
Journal: J Immunol Date: 1986-05-15 Impact factor: 5.422

2. Association between the 7 S RNA and the lupus La protein varies among cell types.

Authors: J C Chambers; M G Kurilla; J D Keene
Journal: J Biol Chem Date: 1983-10-10 Impact factor: 5.157

Review 3. Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.

Authors: E M Tan
Journal: Adv Immunol Date: 1982 Impact factor: 3.543

4. Purified lupus antigen La recognizes an oligouridylate stretch common to the 3' termini of RNA polymerase III transcripts.

Authors: J E Stefano
Journal: Cell Date: 1984-01 Impact factor: 41.582

5. Identification of a La protein binding site in a RNA polymerase III transcript (4.5 I RNA).

Authors: R Reddy; D Henning; E Tan; H Busch
Journal: J Biol Chem Date: 1983-07-10 Impact factor: 5.157

6. Purification and characterization of the Sjögren's syndrome A and B antigens.

Authors: P J Venables; P R Smith; R N Maini
Journal: Clin Exp Immunol Date: 1983-12 Impact factor: 4.330

7. Characterization of a phosphoprotein associated with the SS-B/La nuclear antigen in adenovirus-infected and uninfected KB cells.

Authors: L I Pizer; J S Deng; R M Stenberg; E M Tan
Journal: Mol Cell Biol Date: 1983-07 Impact factor: 4.272

8. Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La lupus antibodies.

Authors: J Rinke; J A Steitz
Journal: Cell Date: 1982-05 Impact factor: 41.582

9. Interaction between VA RNA and the lupus antigen La: formation of a ribonucleoprotein particle in vitro.

Authors: A M Francoeur; M B Mathews
Journal: Proc Natl Acad Sci U S A Date: 1982-11 Impact factor: 11.205

10. A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus.

Authors: J Wilusz; M G Kurilla; J D Keene
Journal: Proc Natl Acad Sci U S A Date: 1983-10 Impact factor: 11.205

12 in total

9. Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies.

Authors: E K Chan; E M Tan
Journal: J Exp Med Date: 1987-12-01 Impact factor: 14.307

10. Analysis of the intracellular localization and assembly of Ro ribonucleoprotein particles by microinjection into Xenopus laevis oocytes.

Authors: F H Simons; G J Pruijn; W J van Venrooij
Journal: J Cell Biol Date: 1994-06 Impact factor: 10.539

The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons.

1. Epitopes, structural domains, and asymmetry of amino acid residues in SS-B/La nuclear protein.

2. Association between the 7 S RNA and the lupus La protein varies among cell types.

Review 3. Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.

4. Purified lupus antigen La recognizes an oligouridylate stretch common to the 3' termini of RNA polymerase III transcripts.

5. Identification of a La protein binding site in a RNA polymerase III transcript (4.5 I RNA).

6. Purification and characterization of the Sjögren's syndrome A and B antigens.

7. Characterization of a phosphoprotein associated with the SS-B/La nuclear antigen in adenovirus-infected and uninfected KB cells.

8. Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La lupus antibodies.

9. Interaction between VA RNA and the lupus antigen La: formation of a ribonucleoprotein particle in vitro.

10. A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus.

Review 1. B-cell epitopes of La and Ro autoantigens.

2. A carboxy-terminal basic region controls RNA polymerase III transcription factor activity of human La protein.

3. Comparison of assay systems for detecting antibodies to nuclear ribonucleoproteins.

Review 4. Structure and function of La and Ro RNPs.

5. 5' processing of tRNA precursors can Be modulated by the human La antigen phosphoprotein.

6. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.

7. La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA.

Review 8. Autoantibodies to tumor-associated antigens: reporters from the immune system.

9. Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies.

10. Analysis of the intracellular localization and assembly of Ro ribonucleoprotein particles by microinjection into Xenopus laevis oocytes.