Elena García-Martín1, Carmen Martínez2, Mercedes Serrador3, Hortensia Alonso-Navarro4, Francisco Navacerrada5, José A G Agúndez6, Félix Javier Jiménez-Jiménez7. 1. Department of Biochemistry & Molecular Biology, University of Extremadura, Cáceres, Spain. 2. Department of Pharmacology, University of Extremadura, Badajoz, Spain. 3. Department of Family Medicine, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. 4. Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. 5. Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Service of Neurology, Hospital "Ramón y Cajal", Universidad de Alcalá, Madrid, Spain. 6. Department of Pharmacology, University of Extremadura, Cáceres, Spain. 7. Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. Electronic address: fjavier.jimenez@salud.madrid.org.
Abstract
BACKGROUND/ OBJECTIVES: Glutamate has been implicated in the pathogenesis of migraine. We investigated the possible association between the polymorphism rs3794087 in the SLC1A2 gene (EATT2 or GLT-1; chromosome 11p13-p12 involved in glutamate transport) and the risk for migraine and for triggering migraine attacks by alcohol. METHODS: We studied the frequency of the rs3794087 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a TaqMan-based qPCR assay. RESULTS: The frequencies of the rs3794087 genotypes and alleles were similar in patients with migraine and controls, and were unrelated with the age of onset of migraine, gender, presence or absence of aura, or family history of migraine CONCLUSION: rs3794087 genotype and allelic variants were not related with the risk for migraine in Caucasian Spanish people.
BACKGROUND/ OBJECTIVES:Glutamate has been implicated in the pathogenesis of migraine. We investigated the possible association between the polymorphism rs3794087 in the SLC1A2 gene (EATT2 or GLT-1; chromosome 11p13-p12 involved in glutamate transport) and the risk for migraine and for triggering migraine attacks by alcohol. METHODS: We studied the frequency of the rs3794087 genotypes and allelic variants in 197 patients with migraine and 308 healthy controls using a TaqMan-based qPCR assay. RESULTS: The frequencies of the rs3794087 genotypes and alleles were similar in patients with migraine and controls, and were unrelated with the age of onset of migraine, gender, presence or absence of aura, or family history of migraine CONCLUSION:rs3794087 genotype and allelic variants were not related with the risk for migraine in Caucasian Spanish people.
Authors: Elena García-Martín; Gara Esguevillas; Mercedes Serrador; Hortensia Alonso-Navarro; Francisco Navacerrada; Gemma Amo; Esteban García-Albea; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: J Neural Transm (Vienna) Date: 2018-01-03 Impact factor: 3.575
Authors: Elena García-Martín; Santiago Navarro-Muñoz; Christopher Rodriguez; Mercedes Serrador; Hortensia Alonso-Navarro; Marisol Calleja; Laura Turpín-Fenoll; Marta Recio-Bermejo; Rafael García-Ruiz; Jorge Millán-Pascual; Francisco Navacerrada; José Francisco Plaza-Nieto; Esteban García-Albea; José A G Agúndez; Félix Javier Jiménez-Jiménez Journal: Pharmacogenomics J Date: 2019-12-03 Impact factor: 3.550
Authors: Hyeonsoo Jeong; Laura S Moye; Bruce R Southey; Alvaro G Hernandez; Isaac Dripps; Elena V Romanova; Stanislav S Rubakhin; Jonathan V Sweedler; Amynah A Pradhan; Sandra L Rodriguez-Zas Journal: Front Syst Neurosci Date: 2018-12-18
Authors: Eric L Brown; Jennifer E Below; Rebecca S B Fischer; Heather T Essigmann; Hao Hu; Chad Huff; D Ashley Robinson; Lauren E Petty; David Aguilar; Graeme I Bell; Craig L Hanis Journal: PLoS One Date: 2015-11-16 Impact factor: 3.240