Literature DB >> 24411937

NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.

Debanjan Dhar1, Ekihiro Seki2, Michael Karin3.   

Abstract

Although type 2 diabetes (T2D) is an established risk factor for hepatocellular carcinoma (HCC), the underlying mechanism that connects these two diseases is unknown. Gao et al. (2013) now suggest that nuclear receptor coactivator 5 (NCOA5) provides a genetic link between the two diseases through its effects on hepatic IL-6 expression.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24411937      PMCID： PMC3947913          DOI： 10.1016/j.cmet.2013.12.010

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

Review 1.  NF-κB and STAT3 - key players in liver inflammation and cancer.

Authors:  Guobin He; Michael Karin
Journal:  Cell Res       Date:  2010-12-28       Impact factor: 25.617

2.  Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

Authors:  Guobin He; Debanjan Dhar; Hayato Nakagawa; Joan Font-Burgada; Hisanobu Ogata; Yuhong Jiang; Shabnam Shalapour; Ekihiro Seki; Shawn E Yost; Kristen Jepsen; Kelly A Frazer; Olivier Harismendy; Maria Hatziapostolou; Dimitrios Iliopoulos; Atsushi Suetsugu; Robert M Hoffman; Ryosuke Tateishi; Kazuhiko Koike; Michael Karin
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

3.  NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma.

Authors:  Shenglan Gao; Aimin Li; Feiye Liu; Fengsheng Chen; Mark Williams; Chengliang Zhang; Zakiya Kelley; Chin-Lee Wu; Rongcheng Luo; Hua Xiao
Journal:  Cancer Cell       Date:  2013-12-09       Impact factor: 31.743

Review 4.  Type 2 diabetes as an inflammatory disease.

Authors:  Marc Y Donath; Steven E Shoelson
Journal:  Nat Rev Immunol       Date:  2011-01-14       Impact factor: 53.106

5.  Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.

Authors:  Joseph P Tiano; Viviane Delghingaro-Augusto; Cedric Le May; Suhuan Liu; Meenakshi K Kaw; Saja S Khuder; Martin G Latour; Surabhi A Bhatt; Kenneth S Korach; Sonia M Najjar; Marc Prentki; Franck Mauvais-Jarvis
Journal:  J Clin Invest       Date:  2011-07-11       Impact factor: 14.808

6.  Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.

Authors:  Joshua P Lewis; Nicholette D Palmer; Jennifer B Ellington; Jasmin Divers; Maggie C Y Ng; Lingyi Lu; Carl D Langefeld; Barry I Freedman; Donald W Bowden
Journal:  Genomics       Date:  2010-07-30       Impact factor: 5.736

7.  IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.

Authors:  Shin Maeda; Hideaki Kamata; Jun-Li Luo; Hyam Leffert; Michael Karin
Journal:  Cell       Date:  2005-07-01       Impact factor: 41.582

Review 8.  Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.

Authors:  Hashem B El-Serag; K Lenhard Rudolph
Journal:  Gastroenterology       Date:  2007-06       Impact factor: 22.682

9.  Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1.

Authors:  Ling Yang; Sayaka Inokuchi; Yoon Seok Roh; Jingyi Song; Rohit Loomba; Eek Joong Park; Ekihiro Seki
Journal:  Gastroenterology       Date:  2013-02-04       Impact factor: 22.682

10.  Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.

Authors:  Willscott E Naugler; Toshiharu Sakurai; Sunhwa Kim; Shin Maeda; Kyounghyun Kim; Ahmed M Elsharkawy; Michael Karin
Journal:  Science       Date:  2007-07-06       Impact factor: 47.728
  10 in total
  8 in total

1.  CCAT1 promotes hepatocellular carcinoma cell proliferation and invasion.

Authors:  Huaqiang Zhu; Xu Zhou; Hong Chang; Hongguang Li; Fangfeng Liu; Chaoqun Ma; Jun Lu
Journal:  Int J Clin Exp Pathol       Date:  2015-05-01

2.  Association between expression of nuclear receptor co-activator 5 protein and prognosis in postoperative patients with osteosarcoma.

Authors:  Ya Wu; Jian Wu; Qi-Rong Dong; Nai-Zhou Guo
Journal:  Oncol Lett       Date:  2017-12-05       Impact factor: 2.967

3.  A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation.

Authors:  Xinhui Liu; Feiye Liu; Shenglan Gao; Jake Reske; Aimin Li; Chin-Lee Wu; Chengfeng Yang; Fengsheng Chen; Rongcheng Luo; Hua Xiao
Journal:  Cancer Lett       Date:  2017-01-27       Impact factor: 8.679

4.  Overexpression of LBH is associated with poor prognosis in human hepatocellular carcinoma.

Authors:  Jiewei Chen; Chuqiang Huang; Keming Chen; Shuman Li; Xinke Zhang; Jun Cheng; Muyan Cai; Yongbo Xiao
Journal:  Onco Targets Ther       Date:  2018-01-19       Impact factor: 4.147

5.  NCOA5 promotes proliferation, migration and invasion of colorectal cancer cells via activation of PI3K/AKT pathway.

Authors:  Kailv Sun; Sheng Wang; Jun He; Yufeng Xie; Yang He; Zhenxin Wang; Lei Qin
Journal:  Oncotarget       Date:  2017-11-14

6.  A novel tumor suppressor gene NCOA5 is correlated with progression in papillary thyroid carcinoma.

Authors:  Zhou-Ci Zheng; Qing-Xuan Wang; Wei Zhang; Xiao-Hua Zhang; Du-Ping Huang
Journal:  Onco Targets Ther       Date:  2018-01-11       Impact factor: 4.147

7.  NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through Increased IL-6 Expression in the Epididymis.

Authors:  Shenglan Gao; Yueqi Zhang; Chengfeng Yang; Gloria I Perez; Hua Xiao
Journal:  Sci Rep       Date:  2019-10-29       Impact factor: 4.379

8.  NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21WAF1/CIP1 overexpression, which is reversed by metformin.

Authors:  Mark Williams; Xinhui Liu; Yueqi Zhang; Jake Reske; Devika Bahal; Trevor G Gohl; Daniel Hollern; Elliot Ensink; Matti Kiupel; Rongcheng Luo; Rupali Das; Hua Xiao
Journal:  Oncogene       Date:  2020-03-20       Impact factor: 9.867
  8 in total

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