Literature DB >> 24411574

Keeping notch target genes off: a CSL corepressor caught in the act.

Tilman Borggrefe1, Franz Oswald2.   

Abstract

In this issue of Structure, Collins and colleagues report the structure of the Notch pathway component CSL bound to the corepressor KyoT2. The structure reveals that KyoT2 interacts with CSL in a configuration similar, but not identical to, the Notch RAM domain and provides insights into how CSL switches from an activator to a repressor.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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Year:  2014        PMID： 24411574     DOI： 10.1016/j.str.2013.12.007

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  6 in total

1.  [Inhibitory effect of KyoT2 overexpression on proliferation and migration of airway smooth muscle cells in mice with asthma].

Authors:  Long Zhao; Cui-Cui Liu; Xiao-Lan Shi; Ning Wang
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2016-09

Review 2.  Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.

Authors:  Jose L Salazar; Shinya Yamamoto
Journal:  Adv Exp Med Biol       Date:  2018       Impact factor: 2.622

3.  Notch-independent RBPJ controls angiogenesis in the adult heart.

Authors:  Ramón Díaz-Trelles; Maria Cecilia Scimia; Paul Bushway; Danh Tran; Anna Monosov; Edward Monosov; Kirk Peterson; Stacey Rentschler; Pedro Cabrales; Pilar Ruiz-Lozano; Mark Mercola
Journal:  Nat Commun       Date:  2016-06-30       Impact factor: 14.919

4.  RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

Authors:  Tao Xu; Sung-Soo Park; Benedetto Daniele Giaimo; Daniel Hall; Francesca Ferrante; Diana M Ho; Kazuya Hori; Lucas Anhezini; Iris Ertl; Marek Bartkuhn; Honglai Zhang; Eléna Milon; Kimberly Ha; Kevin P Conlon; Rork Kuick; Brandon Govindarajoo; Yang Zhang; Yuqing Sun; Yali Dou; Venkatesha Basrur; Kojo Sj Elenitoba-Johnson; Alexey I Nesvizhskii; Julian Ceron; Cheng-Yu Lee; Tilman Borggrefe; Rhett A Kovall; Jean-François Rual
Journal:  EMBO J       Date:  2017-10-13       Impact factor: 11.598

5.  OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor.

Authors:  Gwang Sik Kim; Hee-Sae Park; Young Chul Lee
Journal:  Mol Cells       Date:  2018-08-30       Impact factor: 5.034

6.  Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells.

Authors:  Eike-Benjamin Braune; Yat Long Tsoi; Yee Peng Phoon; Sebastian Landor; Helena Silva Cascales; Daniel Ramsköld; Qiaolin Deng; Arne Lindqvist; Xiaojun Lian; Cecilia Sahlgren; Shao-Bo Jin; Urban Lendahl
Journal:  Stem Cell Reports       Date:  2016-04-07       Impact factor: 7.765
  6 in total

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