Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The bile acid TGR5 membrane receptor: from basic research to clinical application.

Literature DB >> 24411485

The bile acid TGR5 membrane receptor: from basic research to clinical application.

Henri Duboc¹, Yvette Taché², Alan F Hofmann³.

Abstract

The TGR5 receptor (or GP-BAR1, or M-BAR) was characterized ten years ago as the first identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely distributed, including endocrine glands, adipocytes, muscles, immune organs, spinal cord, and the enteric nervous system. The effect of TGR5 activation depends on the tissue where it is expressed and the signalling cascade that it induces. Animal studies suggest that TGR5 activation influences energy production and thereby may be involved in obesity and diabetes. TGR5 activation also influences intestinal motility. This review provides an overview of TGR5-bile acid interactions in health as well as the possible involvement of TGR5 in human disease.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Bile acids; Diabetes; Inflammation; Motility; TGR5 receptor

Mesh：

Substances：

Year: 2014 PMID： 24411485 PMCID： PMC5953190 DOI： 10.1016/j.dld.2013.10.021

Source DB: PubMed Journal: Dig Liver Dis ISSN： 1590-8658 Impact factor: 4.088

92 in total

Review 1. Peripheral mechanisms in irritable bowel syndrome.

Authors: Michael Camilleri
Journal: N Engl J Med Date: 2012-10-25 Impact factor: 91.245

2. Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.

Authors: Anatoliy I Masyuk; Bing Q Huang; Brynn N Radtke; Gabriella B Gajdos; Patrick L Splinter; Tatyana V Masyuk; Sergio A Gradilone; Nicholas F LaRusso
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2013-04-11 Impact factor: 4.052

3. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.

Authors: Guobin He; Guann-Yi Yu; Vladislav Temkin; Hisanobu Ogata; Christian Kuntzen; Toshiharu Sakurai; Wolfgang Sieghart; Markus Peck-Radosavljevic; Hyam L Leffert; Michael Karin
Journal: Cancer Cell Date: 2010-03-16 Impact factor: 31.743

Review 4. TGR5 sequence variation in primary sclerosing cholangitis.

Authors: Johannes R Hov; Verena Keitel; Erik Schrumpf; Dieter Häussinger; Tom H Karlsen
Journal: Dig Dis Date: 2011-06-17 Impact factor: 2.404

Review 5. Perspective: TGR5 (Gpbar-1) in liver physiology and disease.

Authors: Verena Keitel; Dieter Häussinger
Journal: Clin Res Hepatol Gastroenterol Date: 2012-04-18 Impact factor: 2.947

6. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

Authors: Matthew J Potthoff; Austin Potts; Tianteng He; João A G Duarte; Ronald Taussig; David J Mangelsdorf; Steven A Kliewer; Shawn C Burgess
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-12-20 Impact factor: 4.052

7. The TGR5 receptor mediates bile acid-induced itch and analgesia.

Authors: Farzad Alemi; Edwin Kwon; Daniel P Poole; TinaMarie Lieu; Victoria Lyo; Fiore Cattaruzza; Ferda Cevikbas; Martin Steinhoff; Romina Nassini; Serena Materazzi; Raquel Guerrero-Alba; Eduardo Valdez-Morales; Graeme S Cottrell; Kristina Schoonjans; Pierangelo Geppetti; Stephen J Vanner; Nigel W Bunnett; Carlos U Corvera
Journal: J Clin Invest Date: 2013-03-25 Impact factor: 14.808

8. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.

Authors: Johannes R Hov; Verena Keitel; Jon K Laerdahl; Lina Spomer; Eva Ellinghaus; Abdou ElSharawy; Espen Melum; Kirsten M Boberg; Thomas Manke; Tobias Balschun; Christoph Schramm; Annika Bergquist; Tobias Weismüller; Daniel Gotthardt; Christian Rust; Liesbet Henckaerts; Clive M Onnie; Rinse K Weersma; Martina Sterneck; Andreas Teufel; Heiko Runz; Adolf Stiehl; Cyriel Y Ponsioen; Cisca Wijmenga; Morten H Vatn; Pieter C F Stokkers; Severine Vermeire; Christopher G Mathew; Benedicte A Lie; Ulrich Beuers; Michael P Manns; Stefan Schreiber; Erik Schrumpf; Dieter Häussinger; Andre Franke; Tom H Karlsen
Journal: PLoS One Date: 2010-08-25 Impact factor: 3.240

9. Expression and function of the bile acid receptor TGR5 in Kupffer cells.

Authors: Verena Keitel; Markus Donner; Stefanie Winandy; Ralf Kubitz; Dieter Häussinger
Journal: Biochem Biophys Res Commun Date: 2008-05-09 Impact factor: 3.575

10. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.

Authors: Taoufiq Harach; Thijs W H Pols; Mitsunori Nomura; Adriano Maida; Mitsuhiro Watanabe; Johan Auwerx; Kristina Schoonjans
Journal: Sci Rep Date: 2012-05-30 Impact factor: 4.379

130 in total

Review 1. Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.

Authors: Tiangang Li; John Y L Chiang
Journal: Hepatobiliary Surg Nutr Date: 2020-04 Impact factor: 7.293

2. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.

Authors: Prasant Kumar Jena; Lili Sheng; Jacopo Di Lucente; Lee-Way Jin; Izumi Maezawa; Yu-Jui Yvonne Wan
Journal: FASEB J Date: 2018-01-10 Impact factor: 5.191

3. Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.

Authors: Lili Sheng; Prasant Kumar Jena; Hui-Xin Liu; Ying Hu; Nidhi Nagar; Denise N Bronner; Matthew L Settles; Andreas J Bäumler; Yu-Jui Yvonne Wan
Journal: FASEB J Date: 2018-06-08 Impact factor: 5.191

The bile acid TGR5 membrane receptor: from basic research to clinical application.

Review 1. Peripheral mechanisms in irritable bowel syndrome.

2. Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling.

3. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.

Review 4. TGR5 sequence variation in primary sclerosing cholangitis.

Review 5. Perspective: TGR5 (Gpbar-1) in liver physiology and disease.

6. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

7. The TGR5 receptor mediates bile acid-induced itch and analgesia.

8. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.

9. Expression and function of the bile acid receptor TGR5 in Kupffer cells.

10. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.

Review 1. Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease.

2. Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.

3. Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.

4. TGR5 in the Cholangiociliopathies.

5. Bile Acid Receptors and Gastrointestinal Functions.

6. Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism.

Review 7. The physiology underlying Roux-en-Y gastric bypass: a status report.

8. Bile acid signaling and bariatric surgery.

Review 9. Bile acids are nutrient signaling hormones.

Review 10. Therapeutic Targets in Polycystic Liver Disease.