Literature DB >> 24411122

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents.

Kishore Lingam Gangadhara1, Eveline Lescrinier1, Christophe Pannecouque2, Piet Herdewijn3.   

Abstract

A series of α- and β-carboxylated phospholipid prodrugs of dideoxy nucleosides have been synthesized and evaluated against HIV. An increase in biological effect with a factor of 500 has only been observed for the adenine nucleoside, which suggests that this prodrug approach is base specific.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV; Nucleotides; Phospholipids; Prodrugs; d4A

Mesh：

Substances：

Year:  2013        PMID： 24411122     DOI： 10.1016/j.bmcl.2013.12.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Design, synthesis, antiviral activity, and pre-formulation development of poly-L-arginine-fatty acyl derivatives of nucleoside reverse transcriptase inhibitors.

Authors:  Bhanu P Pemmaraju; Swapnil Malekar; Hitesh K Agarwal; Rakesh K Tiwari; Donghoon Oh; Gustavo F Doncel; David R Worthen; Keykavous Parang
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2015       Impact factor: 1.381

2.  Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization.

Authors:  Kishore Lingam Gangadhara; Puneet Srivastava; Jef Rozenski; Henri-Philippe Mattelaer; Volker Leen; Wim Dehaen; Johan Hofkens; Eveline Lescrinier; Piet Herdewijn
Journal:  J Syst Chem       Date:  2014-12-09
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.