Ji Young Jang1, Hongjin Shim2, Seung Hwan Lee1, Jae Gil Lee3. 1. Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. 2. Department of Surgery, Yonsei University Wonju College of Medicine, Wonju-si, Republic of Korea. 3. Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: jakii@yuhs.ac.
Abstract
PURPOSE: The authors designed this study to determine how serum selenium and zinc affect the outcomes of critically ill surgical patients. METHODS: The medical records of 162 patients admitted to a surgical intensive care unit (ICU) from October 2010 to July 2012 and managed for more than 3 days were retrospectively investigated. RESULTS: Overall, the mean patient age was 61.2 ± 15.0 years, and the median ICU stay was 5 (3-115) days. The mean Acute Physiologic and Chronic Health Evaluation II score was 18.0 ± 8.0. Eighteen (11.1%) of the study subjects died in ICU. mean selenium levels were 83.5 ± 23.8 ng/dL in the survivor group and 83.3 ± 29.6 ng/dL in the nonsurvivor group, and corresponding mean zinc levels were 46.3 ± 21.7 and 65.6 ± 41.6 μg/dL, respectively. Mean selenium concentrations were significantly different in patients with and without shock (77.9 ± 25.4 and 87.2 ± 23.1 ng/dL, P = .017). Furthermore, mean serum selenium was lower in patients with sepsis than in traumatic or simply postoperative patients (P < .001 and P = .038). Serum Zn was significantly lower in patients with sepsis than in patients with trauma (43.4 ± 25.4 μg/dL vs 54.8 ± 28.1 μg/dL, P = .038). CONCLUSIONS: To determine the effects of serum selenium and zinc levels on critically ill surgical patients, a large-scale prospective study is needed. Crown
PURPOSE: The authors designed this study to determine how serum selenium and zinc affect the outcomes of critically ill surgical patients. METHODS: The medical records of 162 patients admitted to a surgical intensive care unit (ICU) from October 2010 to July 2012 and managed for more than 3 days were retrospectively investigated. RESULTS: Overall, the mean patient age was 61.2 ± 15.0 years, and the median ICU stay was 5 (3-115) days. The mean Acute Physiologic and Chronic Health Evaluation II score was 18.0 ± 8.0. Eighteen (11.1%) of the study subjects died in ICU. mean selenium levels were 83.5 ± 23.8 ng/dL in the survivor group and 83.3 ± 29.6 ng/dL in the nonsurvivor group, and corresponding mean zinc levels were 46.3 ± 21.7 and 65.6 ± 41.6 μg/dL, respectively. Mean selenium concentrations were significantly different in patients with and without shock (77.9 ± 25.4 and 87.2 ± 23.1 ng/dL, P = .017). Furthermore, mean serum selenium was lower in patients with sepsis than in traumatic or simply postoperative patients (P < .001 and P = .038). Serum Zn was significantly lower in patients with sepsis than in patients with trauma (43.4 ± 25.4 μg/dL vs 54.8 ± 28.1 μg/dL, P = .038). CONCLUSIONS: To determine the effects of serum selenium and zinc levels on critically ill surgical patients, a large-scale prospective study is needed. Crown
Authors: Ata Murat Kaynar; Mary Patricia Nowalk; Chyongchiou Jeng Lin; Krissy K Moehling; Michael Susick; Veli Bakalov; Bruce R Pitt; Daniel J Bain; Ted M Ross; Sean G Saul; Mahlon Raymund; Richard K Zimmerman Journal: Hum Vaccin Immunother Date: 2016-01-11 Impact factor: 3.452