| Literature DB >> 24409990 |
Yaolong Chen1, Wenjun Zhang, Yiguang Zhu, Qingbo Zhang, Xinpeng Tian, Si Zhang, Changsheng Zhang.
Abstract
The piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4'-hydroxylase and PieB2 as a 4'-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin E1 (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring.Entities:
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Year: 2014 PMID： 24409990 DOI： 10.1021/ol4034176
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005