| Literature DB >> 24409389 |
Lucia Zucchelli1, Davide Contini1, Rebecca Re1, Alessandro Torricelli1, Lorenzo Spinelli2.
Abstract
A method for the discrimination of superficial and deep absorption variations by time domain functional near infrared spectroscopy is presented. The method exploits the estimate of the photon time-dependent pathlength in different domains of the sampled medium and makes use of an approach based on time-gating of the photon distribution of time-of-flights. Validation of the method is performed in the two-layer geometry to focus on muscle and head applications. Numerical simulations varied the thickness of the upper layer, the interfiber distance, the shape of the instrument response function and the photon counts. Preliminary results from in vivo data are also shown.Keywords: (170.1470) Blood or tissue constituent monitoring; (170.2655) Functional monitoring and imaging; (170.5280) Photon migration; (170.6920) Time-resolved imaging
Year: 2013 PMID: 24409389 PMCID: PMC3862167 DOI: 10.1364/BOE.4.002893
Source DB: PubMed Journal: Biomed Opt Express ISSN: 2156-7085 Impact factor: 3.732