Cengiz Ozdemir1, Işık Conkbayır2, Aslıhan Kuru2, Hikmet Fırat3, Sinem Nedime Sökücü1, Levent Dalar1, Recai Ergün3, Cağla Pınar Uzunmehmetoğlu3, Dilek Ergün4, Sadık Ardıc3. 1. Yedikule Chest Disease and Thoracic Surgery Education and Research Hospital, Sleep Laboratory, İstanbul, Turkey; 2. Department of Radiology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey; 3. Department of Chest Diseases, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey; 4. Occupational Disease Hospital, Department of Chest Diseases, Ankara, Turkey.
Abstract
BACKGROUND: In the present study, we want to demonstrate the correlation between obstructive sleep apnea syndrome (OSAS) whose independent effect on carotid artery intima-media thickness (IMT) was demonstrated, with Framingham risk score (FRS) showing the overall cardiovascular risk. METHODS: IMT of the carotid artery was measured with ultrasonography and 10-year risk of coronary heart disease (CHD) was defined with FRS in 90 consecutive patients referred to our sleep clinic and who underwent polysomnography (PSG), with vascular risk factors and without a clinical atherosclerotic disease. RESULTS: IMT and FRS were found to be statistically significantly increased in the severe OSAS group compared to the other two groups. Carotid IMT was found to be significantly positively correlated with, apnea-hypopnea index (AHI), oxygen desaturation index (ODI) and time duration with oxygen saturation (SpO2) <90%, and negatively correlated with minimum oxygen saturation at sleep (minimum SpO2) and mean SpO2. In control and mild OSAS group IMT and FRS have significantly positive correlation (r: 0.501, P: 0.027; r: 0.625, P<0.001), while in severe OSAS group no significant correlation was detected between IMT and FRS (r: 0.321, P: 0.06). In the regression analysis AHI and ODI were found to be an independent predictor of carotid IMT. ODI was found to have an independent effect on the progression of atherosclerosis. CONCLUSIONS: Increased carotid IMT in severe OSAS group could not be explained with the classical risk factors. In this respect, FRS might be insufficient to determine correctly the cardiovascular risk and protection strategies against the disease in OSAS patients.
BACKGROUND: In the present study, we want to demonstrate the correlation between obstructive sleep apnea syndrome (OSAS) whose independent effect on carotid artery intima-media thickness (IMT) was demonstrated, with Framingham risk score (FRS) showing the overall cardiovascular risk. METHODS: IMT of the carotid artery was measured with ultrasonography and 10-year risk of coronary heart disease (CHD) was defined with FRS in 90 consecutive patients referred to our sleep clinic and who underwent polysomnography (PSG), with vascular risk factors and without a clinical atherosclerotic disease. RESULTS: IMT and FRS were found to be statistically significantly increased in the severe OSAS group compared to the other two groups. Carotid IMT was found to be significantly positively correlated with, apnea-hypopnea index (AHI), oxygen desaturation index (ODI) and time duration with oxygen saturation (SpO2) <90%, and negatively correlated with minimum oxygen saturation at sleep (minimum SpO2) and mean SpO2. In control and mild OSAS group IMT and FRS have significantly positive correlation (r: 0.501, P: 0.027; r: 0.625, P<0.001), while in severe OSAS group no significant correlation was detected between IMT and FRS (r: 0.321, P: 0.06). In the regression analysis AHI and ODI were found to be an independent predictor of carotid IMT. ODI was found to have an independent effect on the progression of atherosclerosis. CONCLUSIONS: Increased carotid IMT in severe OSAS group could not be explained with the classical risk factors. In this respect, FRS might be insufficient to determine correctly the cardiovascular risk and protection strategies against the disease in OSAS patients.
Authors: Raquel Campuzano; José L Moya; Alberto García-Lledó; Juan P Tomas; Soledad Ruiz; Alicia Megías; Javier Balaguer; Enrique Asín Journal: J Hypertens Date: 2006-08 Impact factor: 4.844
Authors: Luciano F Drager; Luiz A Bortolotto; Maria Cecília Lorenzi; Adelaide C Figueiredo; Eduardo M Krieger; Geraldo Lorenzi-Filho Journal: Am J Respir Crit Care Med Date: 2005-05-18 Impact factor: 21.405
Authors: D H O'Leary; J F Polak; R A Kronmal; P J Savage; N O Borhani; S J Kittner; R Tracy; J M Gardin; T R Price; C D Furberg Journal: Stroke Date: 1996-02 Impact factor: 7.914
Authors: Lyn Kieltyka; Elaine M Urbina; Rong Tang; M Gene Bond; Sathanur R Srinivasan; Gerald S Berenson Journal: Atherosclerosis Date: 2003-09 Impact factor: 5.162
Authors: David S Hui; Qing Shang; Fanny W Ko; Susanna S Ng; Cheuk-Chun Szeto; Jenny Ngai; Alvin H Tung; Kin-Wang To; Tat-On Chan; Cheuk-Man Yu Journal: Respir Res Date: 2012-03-16
Authors: Sverrir I Gunnarsson; Paul E Peppard; Claudia E Korcarz; Jodi H Barnet; Erika W Hagen; K Mae Hla; Mari Palta; Terry Young; James H Stein Journal: J Sleep Res Date: 2015-06-22 Impact factor: 3.981