RATIONALE AND OBJECTIVE: Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments. METHODS: We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available n = 1,075). RESULTS: A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [F(2, 1,063) = 7.2, p < 0.001]. Females with the s/s genotype in the older cohort were the latest experimenters with alcohol, while the s/s females of younger cohort had tried alcohol earlier than any other group. In males, there was no significant cohort × genotype interaction, but the 5-HTTLPR genotype was associated with alcohol use, the s/s subjects reporting the highest consumption. CONCLUSION: Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.
RATIONALE AND OBJECTIVE: Prevalence of alcohol use is markedly influenced by socioeconomic conditions and is therefore subject to cohort effects. The common genetic variation 5-HTTLPR (serotonin transporter gene-linked polymorphic region) has been related to several aspects of alcohol use and addiction but with mixed results, probably due to different environmental interaction effects. We aimed at assessing whether the association between alcohol use and 5-HTTLPR genotype is subject to cohort effects as birth cohorts may be raised in significantly different environments. METHODS: We used the database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998). Cohorts of initially 9-year-old (recalled at ages 15 and 18) and 15-year-old (recalled at ages 18 and 25) children provided self-reports on their alcohol use in all data collection waves (complete data available n = 1,075). RESULTS: A significant genotype × gender × cohort interaction effect on the age of consuming the first alcoholic drink was found [F(2, 1,063) = 7.2, p < 0.001]. Females with the s/s genotype in the older cohort were the latest experimenters with alcohol, while the s/s females of younger cohort had tried alcohol earlier than any other group. In males, there was no significant cohort × genotype interaction, but the 5-HTTLPR genotype was associated with alcohol use, the s/s subjects reporting the highest consumption. CONCLUSION: Expression of genetic vulnerability to alcohol use is influenced by birth cohort effects. The 5-HTTLPR genotype is associated with alcohol consumption in general population, but the effect depends on gender and birth cohort.
Authors: Xianzhang Hu; Gabor Oroszi; Jeffrey Chun; Tom L Smith; David Goldman; Marc A Schuckit Journal: Alcohol Clin Exp Res Date: 2005-01 Impact factor: 3.455
Authors: G R Twitchell; G L Hanna; E H Cook; S F Stoltenberg; H E Fitzgerald And; R A Zucker Journal: Alcohol Clin Exp Res Date: 2001-07 Impact factor: 3.455
Authors: Henrik Rasmussen; Yu Bagger; Laszlo B Tanko; Claus Christiansen; Thomas Werge Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2009-06-05 Impact factor: 3.568
Authors: Ahmad R Hariri; Venkata S Mattay; Alessandro Tessitore; Bhaskar Kolachana; Francesco Fera; David Goldman; Michael F Egan; Daniel R Weinberger Journal: Science Date: 2002-07-19 Impact factor: 47.728
Authors: Julia D Grant; Arpana Agrawal; Kathleen K Bucholz; Pamela A F Madden; Michele L Pergadia; Elliot C Nelson; Michael T Lynskey; Richard D Todd; Alexandre A Todorov; Narelle K Hansell; John B Whitfield; Nicholas G Martin; Andrew C Heath Journal: Biol Psychiatry Date: 2009-07-03 Impact factor: 13.382
Authors: Nicholas D Walsh; Tim Dalgleish; Valerie J Dunn; Rosemary Abbott; Michelle C St Clair; Matthew Owens; Graeme Fairchild; William S Kerslake; Lucy V Hiscox; Luca Passamonti; Michael Ewbank; Maria Ban; Andrew J Calder; Ian M Goodyer Journal: Neuroimage Date: 2012-08-21 Impact factor: 6.556
Authors: Lars Oreland; Gianvito Lagravinese; Simone Toffoletto; Kent W Nilsson; Jaanus Harro; C Robert Cloninger; Erika Comasco Journal: J Neural Transm (Vienna) Date: 2017-01-04 Impact factor: 3.575
Authors: Carlos Eduardo Coral de Oliveira; Julie Massayo Maeda Oda; Carolina Batista Ariza; Roberta Losi Guembarovski; Bruna Karina Banin Hirata; Felipe Campos de Almeida; Nayara Delgado André; Maria Helena Pelegrinelli Fungaro; Maria Angelica Ehara Watanabe Journal: J Can Acad Child Adolesc Psychiatry Date: 2016-02-01