Santanu Biswas1, Pradip K Ghoshal2, Bhubaneswar Halder2, Kajal Ganguly2, Arup DasBiswas2, Nripendranath Mandal3. 1. Division of Molecular Medicine, Bose Institute, P-1/12 CIT Scheme VIIM, Kolkata 700054, India. 2. Department of Cardiology, N.R.S. Medical College & Hospital, 138 A.J.C. Bose Road, Kolkata 700014, India. 3. Division of Molecular Medicine, Bose Institute, P-1/12 CIT Scheme VIIM, Kolkata 700054, India. Electronic address: drnmandal@gmail.com.
Abstract
AIM: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). METHODS: We determined distribution of MspI apo AI, EcoRI apo B, HhaI apo E gene polymorphisms, plasma apolipoproteins and lipids levels among 150 patients having CAD admitted to the Department of Cardiology, N.R.S. Medical College & Hospital, Kolkata, India during June 2010-June 2012 and 150 age sex matched healthy controls. RESULTS: We found that ApoAI concentration of studied population was significantly different in each genotypes of -75 G/A apo AI (p < 0.0001) gene polymorphism. A significant association was found in multivariate analysis for the genotypes with apo E4 allele [odds ratio (OR): 3.639; 95% confidence interval (CI): 1.019-12.995, p = 0.040] with four conventional risk factors (i.e. smoking, low-density lipoprotein, ApoAI and ApoB) with CAD. In contrast E2 allele has reverse effect, but the genotypes with apo E2 allele was no longer significant in the multivariate model (OR: 1.788; 95% CI: 0.400-8.001, p = 0.447) where as being significant in univariate analysis (OR: 0.219; 95% CI: 0.087-0.552, p = 0.001). CONCLUSIONS: Our findings suggest that the polymorphisms apo AI MspI and apo B EcoRI do not seem to affect CAD. But the genotype with E4 allele of apo E gene independent of other risk factors is associated with this disease.
AIM: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). METHODS: We determined distribution of MspI apo AI, EcoRI apo B, HhaI apo E gene polymorphisms, plasma apolipoproteins and lipids levels among 150 patients having CAD admitted to the Department of Cardiology, N.R.S. Medical College & Hospital, Kolkata, India during June 2010-June 2012 and 150 age sex matched healthy controls. RESULTS: We found that ApoAI concentration of studied population was significantly different in each genotypes of -75 G/A apo AI (p < 0.0001) gene polymorphism. A significant association was found in multivariate analysis for the genotypes with apo E4 allele [odds ratio (OR): 3.639; 95% confidence interval (CI): 1.019-12.995, p = 0.040] with four conventional risk factors (i.e. smoking, low-density lipoprotein, ApoAI and ApoB) with CAD. In contrast E2 allele has reverse effect, but the genotypes with apo E2 allele was no longer significant in the multivariate model (OR: 1.788; 95% CI: 0.400-8.001, p = 0.447) where as being significant in univariate analysis (OR: 0.219; 95% CI: 0.087-0.552, p = 0.001). CONCLUSIONS: Our findings suggest that the polymorphisms apo AI MspI and apo B EcoRI do not seem to affect CAD. But the genotype with E4 allele of apo E gene independent of other risk factors is associated with this disease.
Authors: R A Hegele; L S Huang; P N Herbert; C B Blum; J E Buring; C H Hennekens; J L Breslow Journal: N Engl J Med Date: 1986-12-11 Impact factor: 91.245
Authors: T J Knott; S C Rall; T L Innerarity; S F Jacobson; M S Urdea; B Levy-Wilson; L M Powell; R J Pease; R Eddy; H Nakai Journal: Science Date: 1985-10-04 Impact factor: 47.728
Authors: Wisam Jasim Mohammed; Bassam Musa Sadik Al-Musawi; Christian Oberkanins; Helene Pühringer Journal: Int J Health Sci (Qassim) Date: 2018 May-Jun