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Literature DB >> 24407423

Digital response in T cells: to be or not to be.

Abstract

A recent study published in Immunity shows that foreign antigens elicit all-or-nothing T cell responses and that a single antigen is enough to trigger this digital cytokine secretion.

Mesh：

Substances：

Year: 2014 PMID： 24407423 PMCID： PMC3945894 DOI： 10.1038/cr.2014.5

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

9 in total

1. CRAC channels drive digital activation and provide analog control and synergy to Ca(2+)-dependent gene regulation.

Authors: Pulak Kar; Charmaine Nelson; Anant B Parekh
Journal: Curr Biol Date: 2012-01-12 Impact factor: 10.834

Review 2. Neural coding: hybrid analog and digital signalling in axons.

Authors: Beverley Clark; Michael Häusser
Journal: Curr Biol Date: 2006-08-08 Impact factor: 10.834

3. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.

Authors: Jun Huang; Mario Brameshuber; Xun Zeng; Jianming Xie; Qi-jing Li; Yueh-hsiu Chien; Salvatore Valitutti; Mark M Davis
Journal: Immunity Date: 2013-10-10 Impact factor: 31.745

4. Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.

Authors: Savaş Tay; Jacob J Hughey; Timothy K Lee; Tomasz Lipniacki; Stephen R Quake; Markus W Covert
Journal: Nature Date: 2010-06-27 Impact factor: 49.962

5. Cutting edge: TCR ligation triggers digital activation of NF-kappaB.

Authors: Lara M Kingeter; Suman Paul; Sean K Maynard; Natalia G Cartwright; Brian C Schaefer
Journal: J Immunol Date: 2010-09-20 Impact factor: 5.422

6. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways.

Authors: Irena Stefanová; Bernhard Hemmer; Marco Vergelli; Roland Martin; William E Biddison; Ronald N Germain
Journal: Nat Immunol Date: 2003-02-10 Impact factor: 25.606

7. Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Authors: Jayajit Das; Mary Ho; Julie Zikherman; Christopher Govern; Ming Yang; Arthur Weiss; Arup K Chakraborty; Jeroen P Roose
Journal: Cell Date: 2009-01-23 Impact factor: 41.582

8. Modeling T cell antigen discrimination based on feedback control of digital ERK responses.

Authors: Grégoire Altan-Bonnet; Ronald N Germain
Journal: PLoS Biol Date: 2005-10-25 Impact factor: 8.029

9. Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression.

Authors: Miriam Podtschaske; Uwe Benary; Sandra Zwinger; Thomas Höfer; Andreas Radbruch; Ria Baumgrass
Journal: PLoS One Date: 2007-09-26 Impact factor: 3.240

9 in total

8 in total

1. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.

Authors: Burak Dura; Mariah M Servos; Rachel M Barry; Hidde L Ploegh; Stephanie K Dougan; Joel Voldman
Journal: Proc Natl Acad Sci U S A Date: 2016-06-14 Impact factor: 11.205

2. Elastomeric sensor surfaces for high-throughput single-cell force cytometry.

Authors: Ivan Pushkarsky; Peter Tseng; Dylan Black; Bryan France; Lyndon Warfe; Cynthia J Koziol-White; William F Jester; Ryan K Trinh; Jonathan Lin; Philip O Scumpia; Sherie L Morrison; Reynold A Panettieri; Robert Damoiseaux; Dino Di Carlo
Journal: Nat Biomed Eng Date: 2018-02-06 Impact factor: 25.671

Digital response in T cells: to be or not to be.

1. CRAC channels drive digital activation and provide analog control and synergy to Ca(2+)-dependent gene regulation.

Review 2. Neural coding: hybrid analog and digital signalling in axons.

3. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.

4. Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.

5. Cutting edge: TCR ligation triggers digital activation of NF-kappaB.

6. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways.

7. Digital signaling and hysteresis characterize ras activation in lymphoid cells.

8. Modeling T cell antigen discrimination based on feedback control of digital ERK responses.

9. Digital NFATc2 activation per cell transforms graded T cell receptor activation into an all-or-none IL-2 expression.

1. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.

2. Elastomeric sensor surfaces for high-throughput single-cell force cytometry.

3. Temporal signaling, population control, and information processing through chromatin-mediated gene regulation.

4. Negative regulation of TCR signaling by ubiquitination of Zap-70 Lys-217.

5. Inferring the Effects of Honokiol on the Notch Signaling Pathway in SW480 Colon Cancer Cells.

6. The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation.

7. Simulation of Stimulation: Cytokine Dosage and Cell Cycle Crosstalk Driving Timing-Dependent T Cell Differentiation.

Review 8. Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins.