Literature DB >> 2440700

Galanin stimulates growth hormone (GH) secretion via GH-releasing factor (GRF) in conscious rats.

Y Murakami, Y Kato, H Koshiyama, T Inoue, N Yanaihara, H Imura.   

Abstract

The possibility of a role of hypothalamic growth hormone (GH)-releasing factor (GRF) in GH secretion induced by centrally administered galanin was investigated in freely moving male rats. Intracerebroventricular (i.c.v.) injection of synthetic galanin (0.4 or 2 micrograms/rat) elicited a dose-related increase in plasma GH in these conscious rats. Pretreatment with rabbit antiserum specific for rat GRF significantly inhibited the plasma GH increase induced by i.c.v. injection of galanin (2 micrograms/rat). These findings suggest that galanin-induced GH secretion in the rat is mediated at least in part by hypothalamic GRF.

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Year:  1987        PMID： 2440700     DOI： 10.1016/0014-2999(87)90316-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

Review 1.  Galanin.

Authors:  M E Vrontakis; A Torsello; H G Friesen
Journal:  J Endocrinol Invest       Date:  1991-10       Impact factor: 4.256

Review 2.  Gene expression and chemical diversity in hypothalamic neurosecretory neurons.

Authors:  B Meister
Journal:  Mol Neurobiol       Date:  1993       Impact factor: 5.590

Review 3.  Galanin-acetylcholine interactions in rodent memory tasks and Alzheimer's disease.

Authors:  M P McDonald; J N Crawley
Journal:  J Psychiatry Neurosci       Date:  1997-11       Impact factor: 6.186

4.  Colocalization of galanin and luteinizing hormone-releasing hormone in a subset of preoptic hypothalamic neurons: anatomical and functional correlates.

Authors:  I Merchenthaler; F J Lopez; A Negro-Vilar
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

Review 5.  Galanin and its receptors in neurological disorders.

Authors:  Linda Lundström; Anna Elmquist; Tamas Bartfai; Ulo Langel
Journal:  Neuromolecular Med       Date:  2005       Impact factor: 3.843

6.  Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: effects of monosodium glutamate (MSG) lesions.

Authors:  B Meister; S Ceccatelli; T Hökfelt; N E Andén; M Andén; E Theodorsson
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

7.  Galanin infusion partially restores the blunted growth hormone responses to repeated growth hormone releasing hormone stimuli in normal adults.

Authors:  A Sartorio; A Spada; A Conti; G Grugni; F Morabito; G Faglia
Journal:  J Endocrinol Invest       Date:  1993-02       Impact factor: 4.256

8.  Peptidylglycine alpha-amidating monooxygenase (PAM) immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary tumours.

Authors:  J H Steel; A Martínez; D R Springall; A M Treston; F Cuttitta; J M Polak
Journal:  Cell Tissue Res       Date:  1994-04       Impact factor: 5.249

9.  Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary.

Authors:  L M Kaplan; S M Gabriel; J I Koenig; M E Sunday; E R Spindel; J B Martin; W W Chin
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice.

Authors:  Anca D Petrescu; Stephanie Grant; Elaina Williams; Gabriel Frampton; Natalie Parks; Hanna Blaney; Marcus Davies; Rebekah John; Evan H Reinhart; Matthew McMillin; Sharon DeMorrow
Journal:  Am J Pathol       Date:  2020-01-14       Impact factor: 4.307
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