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Literature DB >> 2440628

Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts.

S Bandyopadhyay, D S Miller, M Matsumoto-Kobayashi, S C Clark, S E Starr.

Abstract

The ability of nonadherent peripheral blood mononuclear cells of normal individuals to lyse noninfected and cytomegalovirus (CMV)-infected human fibroblasts was enhanced by preincubation with recombinant human alpha interferon (alpha-rIFN) or beta (beta-rIFN). In contrast, recombinant human gamma IFN (gamma-rIFN) augmented natural killing (NK) against both targets relatively poorly. Recombinant or natural human interleukin 2(IL-2) also augmented NK against noninfected and CMV-infected targets. Augmentation of NK by IFN or IL-2 could be blocked by the addition of corresponding antisera. IL-2-enhanced NK against CMV-infected targets was usually independent of alpha-IFN production.

Entities: Chemical Disease Gene Species

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Year: 1987 PMID： 2440628 PMCID： PMC1542584

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

37 in total

1. Plaque assay of cytomegalovirus strains of human origin.

Authors: B B Wentworth; L French
Journal: Proc Soc Exp Biol Med Date: 1970-11

2. Enhancement of T cell cytotoxic responses by purified human fibroblast interferon.

Authors: J M Zarling; J Sosman; L Eskra; E C Borden; J S Horoszewicz; W A Carter
Journal: J Immunol Date: 1978-11 Impact factor: 5.422

3. Virus-specific cytotoxic lymphocyte responses are predictive of the outcome of cytomegalovirus infection of renal transplant recipients.

Authors: A H Rook; W J Smith; J F Burdick; J F Manischewitz; W Frederick; J P Siegel; G M Williams; G V Quinnan
Journal: Transplant Proc Date: 1984-12 Impact factor: 1.066

4. Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

Authors: J R Ortaldo; A T Mason; J P Gerard; L E Henderson; W Farrar; R F Hopkins; R B Herberman; H Rabin
Journal: J Immunol Date: 1984-08 Impact factor: 5.422

1. Low-dose human cytomegalovirus infection of human fibroblast cultures induces lymphokine-activated killer cell resistance: interferon-beta-mediated target cell protection does not correlate with up-regulation of HLA class I surface molecules.

Authors: K Hamprecht; M Steinmassl
Journal: Immunology Date: 1994-06 Impact factor: 7.397

1 in total

Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts.

1. Plaque assay of cytomegalovirus strains of human origin.

2. Enhancement of T cell cytotoxic responses by purified human fibroblast interferon.

3. Virus-specific cytotoxic lymphocyte responses are predictive of the outcome of cytomegalovirus infection of renal transplant recipients.

4. Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

5. Effect of interferon alpha on natural killer cell cytotoxicity in kidney transplant recipients.

6. Potentiation of Leu 11 + natural cytotoxicity by human interleukin 2.

7. Deficient natural killer function in patients receiving immunosuppressive drugs: analysis at the cellular level.

8. Augmentation of human natural cell-mediated cytotoxicity by recombinant human interleukin 2.

9. Long-term culture of human antigen-specific cytotoxic T-cell lines.

10. Response of resting human peripheral blood natural killer cells to interleukin 2.

1. Low-dose human cytomegalovirus infection of human fibroblast cultures induces lymphokine-activated killer cell resistance: interferon-beta-mediated target cell protection does not correlate with up-regulation of HLA class I surface molecules.