| Literature DB >> 24405705 |
Thorsten A Kirschberg1, Neil H Squires2, Huiling Yang3, Amoreena C Corsa3, Yang Tian3, Neeraj Tirunagari3, X Christopher Sheng2, Choung U Kim4.
Abstract
A sulfonamide replacement of the P2-P3 amide bond in the context of macrocyclic HCV NS3 protease inhibitors was investigated. These analogs displayed good inhibitory potency in the absence of any P3 capping group. The synthesis and preliminary SAR are described.Entities:
Keywords: HCV; NS3 protease; Sulfonamide
Mesh：
Substances：
Year: 2013 PMID： 24405705 DOI： 10.1016/j.bmcl.2013.12.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823