Qin Wu1, Jianan Ren2, Xiuwen Wu1, Gefei Wang1, Guosheng Gu1, Song Liu1, Yin Wu1, Dong Hu1, Yunzhao Zhao1, Jieshou Li1. 1. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. 2. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: JiananR@gmail.com.
Abstract
INTRODUCTION: Thrombocytopenia is prevalent in patients with severe sepsis, and it is associated with mortalities. Effectively adjunctive treatment might be needed to reverse low platelet counts (PCs). With a growing understanding of thrombocytopenia, recombinant human thrombopoietin (rhTPO) is considered a promising beneficial drug. The present study was dedicated to evaluate the efficiency of rhTPO in improving PCs in patients with severe sepsis. MATERIALS AND METHODS: We performed a prospective study in patients with severe sepsis between March 2012 and February 2013. All enrolled patients were divided into rhTPO group and control group, depending on whether rhTPO was prescribed or not. Platelet counts and other parameters were measured initially and in the following 15 days. RESULTS: Totally, 72 patients (38 in the rhTPO group and 34 in the control group) were included. All enrolled parameters exhibited no significant differences between groups at the baseline. Platelet counts showed a significant increase over time in both groups. Faster improvement of PCs in the rhTPO group was observed with a significant difference. Less platelet transfusion occurred in patients who received rhTPO in our study, as well. No drug-related adverse event during the rhTPO therapy was recorded. CONCLUSION: The use of rhTPO in combination with conventional medical therapies could significantly improve the PCs in patients with severe sepsis and thrombocytopenia and effectively reduce the platelet transfusion possibility.
INTRODUCTION:Thrombocytopenia is prevalent in patients with severe sepsis, and it is associated with mortalities. Effectively adjunctive treatment might be needed to reverse low platelet counts (PCs). With a growing understanding of thrombocytopenia, recombinant humanthrombopoietin (rhTPO) is considered a promising beneficial drug. The present study was dedicated to evaluate the efficiency of rhTPO in improving PCs in patients with severe sepsis. MATERIALS AND METHODS: We performed a prospective study in patients with severe sepsis between March 2012 and February 2013. All enrolled patients were divided into rhTPO group and control group, depending on whether rhTPO was prescribed or not. Platelet counts and other parameters were measured initially and in the following 15 days. RESULTS: Totally, 72 patients (38 in the rhTPO group and 34 in the control group) were included. All enrolled parameters exhibited no significant differences between groups at the baseline. Platelet counts showed a significant increase over time in both groups. Faster improvement of PCs in the rhTPO group was observed with a significant difference. Less platelet transfusion occurred in patients who received rhTPO in our study, as well. No drug-related adverse event during the rhTPO therapy was recorded. CONCLUSION: The use of rhTPO in combination with conventional medical therapies could significantly improve the PCs in patients with severe sepsis and thrombocytopenia and effectively reduce the platelet transfusion possibility.
Authors: Michael Desborough; Lise J Estcourt; Carolyn Doree; Marialena Trivella; Sally Hopewell; Simon J Stanworth; Michael F Murphy Journal: Cochrane Database Syst Rev Date: 2016-08-22
Authors: Antoine Dewitte; Sébastien Lepreux; Julien Villeneuve; Claire Rigothier; Christian Combe; Alexandre Ouattara; Jean Ripoche Journal: Ann Intensive Care Date: 2017-12-01 Impact factor: 6.925