Literature DB >> 2440525

Blood pressure modulation by substance P in the rat nucleus tractus solitarius.

T Kubo, M Kihara.   

Abstract

Substance P in a dose of 0.1-10 ng injected into the nucleus tractus solitarii (NTS) of the rat caused hypotension, bradycardia and apnea whereas a dose of 100 ng led to no response. A substance P antagonist injected into the NTS abolished the cardiovascular responses to substance P. The antagonist alone increased blood pressure and heart rate. The data suggest a role for substance P in the cardiovascular regulation by the NTS.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2440525     DOI： 10.1016/0006-8993(87)91033-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  5 in total

1.  Activation of NK₁ receptors in the locus coeruleus induces analgesia through noradrenergic-mediated descending inhibition in a rat model of neuropathic pain.

Authors:  Y Muto; A Sakai; A Sakamoto; H Suzuki
Journal:  Br J Pharmacol       Date:  2012-06       Impact factor: 8.739

2.  Capsaicin-sensitive afferents and blood pressure regulation during pentobarbital anaesthesia in the rat.

Authors:  T Bramhall; M Decrinis; J Donnerer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-05       Impact factor: 3.000

3.  Modulation of the aortic baroreceptor reflex by neuropeptide Y, neurotensin and vasopressin microinjected into the nucleus tractus solitarii of the rat.

Authors:  T Kubo; M Kihara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-08       Impact factor: 3.000

Review 4.  Putative roles of neuropeptides in vagal afferent signaling.

Authors:  Guillaume de Lartigue
Journal:  Physiol Behav       Date:  2014-03-18

5.  Colocalization of neurokinin-1, N-methyl-D-aspartate, and AMPA receptors on neurons of the rat nucleus tractus solitarii.

Authors:  L H Lin; O M Taktakishvili; W T Talman
Journal:  Neuroscience       Date:  2008-04-08       Impact factor: 3.590
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.