| Literature DB >> 24405012 |
Hong Yan Yue1, Shuo Huang, Jian Chang, Chaejeong Heo, Fei Yao, Subash Adhikari, Fethullah Gunes, Li Chun Liu, Tae Hoon Lee, Eung Seok Oh, Bing Li, Jian Jiao Zhang, Ta Quang Huy, Nguyen Van Luan, Young Hee Lee.
Abstract
We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson's disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.Entities:
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Year: 2014 PMID： 24405012 DOI： 10.1021/nn405961p
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881