Literature DB >> 24404444

Ternary hybrid nanocomposites for gene delivery and magnetic resonance imaging of hepatocellular carcinoma cells.

Ken Cham-Fai Leung1, Chi-Hin Wong1, Xiao-Ming Zhu2, Siu-Fung Lee3, Kathy W Y Sham4, Josie M Y Lai4, Chun-Pong Chak3, Yi-Xiang J Wang5, Christopher H K Cheng4.   

Abstract

This paper describes comparative studies in magnetic resonance imaging (MRI) and gene deliveries toward hepatocellular carcinoma (HCC) HepG2 cells with ternary composites that consist of superparamagnetic iron oxide (SPIO) nanoparticles (NPs) (8-10 nm) with deferoxamine coating, circular plasmid DNA (~4 kb) equipped with green fluorescent probe, and branched polyethylenimine (PEI) (25 kDa, PDI 2.5). The packaging of the ternary complexes has been characterized by agarose gel retardation assay. By tuning the PEI/NP ratios and with a fixed DNA amount, different ternary composites have been employed for NP/gene transfection towards HepG2 cells, which have been characterized by in vitro MRI and green fluorescence protein (GFP) fluorescence.

Entities:  

Keywords:  Deferoxamine; gene delivery; hepatocellular carcinoma (HCC); magnetic resonance imaging (MRI); superparamagnetic iron oxide (SPIO)

Year:  2013        PMID： 24404444      PMCID： PMC3882806          DOI： 10.3978/j.issn.2223-4292.2013.12.05

Source DB:  PubMed          Journal:  Quant Imaging Med Surg        ISSN： 2223-4306


  33 in total

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