Rony Gelman1, Emily A DiMango2, William M Schiff3. 1. Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Los Angeles, CA ; Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY. 2. Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY. 3. Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY ; Mannhattan Eye, Ear, and Throat Hospital, New York, NY.
Abstract
PURPOSE: To report a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up. METHODS: Observational case report of one patient. RESULTS: A 31 year-old male with a history of cystic fibrosis presented with a central retinal vein occlusion (CRVO) in his left eye, followed by a CRVO in his right eye 4 years later. His medical workup was significant for elevated levels of homocysteine and gamma-globulins, which coincided with initiation of intravenous immunoglobulin (IVIG) proceeding his second CRVO. CONCLUSIONS: We describe a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up and discuss the important role of these risk factors in retinal venous occlusive disease.
PURPOSE: To report a case of sequential bilateral central retinal vein occlusions in a cystic fibrosispatient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up. METHODS: Observational case report of one patient. RESULTS: A 31 year-old male with a history of cystic fibrosis presented with a central retinal vein occlusion (CRVO) in his left eye, followed by a CRVO in his right eye 4 years later. His medical workup was significant for elevated levels of homocysteine and gamma-globulins, which coincided with initiation of intravenous immunoglobulin (IVIG) proceeding his second CRVO. CONCLUSIONS: We describe a case of sequential bilateral central retinal vein occlusions in a cystic fibrosispatient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up and discuss the important role of these risk factors in retinal venous occlusive disease.
Entities:
Keywords:
IVIG; central retinal vein occlusion; cystic fibrosis; gamma-globulin; homocysteine
Authors: M J Stampfer; M R Malinow; W C Willett; L M Newcomer; B Upson; D Ullmann; P V Tishler; C H Hennekens Journal: JAMA Date: 1992-08-19 Impact factor: 56.272
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