BACKGROUND/AIM: The overexpressed in lung cancer-1 (OLC1) protein is overexpressed in a variety of human tumors. The purpose of the present study was to determine whether increased expression of OLC1 is associated with colorectal cancer. MATERIALS AND METHODS: OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining (IHC). Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis. RESULTS: Immunohistochemical results revealed that 107 out of 150 colorectal cancer patients had increased levels of OLC1. OLC1 expression was significantly correlated with UICC stage (p<0.001) and histological differentiation (p<0.001) in colorectal cancer patients. The 5-year overall survival (OS) rates in patients with strong-positive and weak OLC1 staining were 16.6% and 95.3%, respectively (p<0.0001). CONCLUSION: OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.
BACKGROUND/AIM: The overexpressed in lung cancer-1 (OLC1) protein is overexpressed in a variety of humantumors. The purpose of the present study was to determine whether increased expression of OLC1 is associated with colorectal cancer. MATERIALS AND METHODS:OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining (IHC). Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis. RESULTS: Immunohistochemical results revealed that 107 out of 150 colorectal cancerpatients had increased levels of OLC1. OLC1 expression was significantly correlated with UICC stage (p<0.001) and histological differentiation (p<0.001) in colorectal cancerpatients. The 5-year overall survival (OS) rates in patients with strong-positive and weak OLC1 staining were 16.6% and 95.3%, respectively (p<0.0001). CONCLUSION:OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.
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Keywords:
Overexpressed in lung cancer 1 (OLC1); colorectal cancer; immunohistochemistry; prognosis
Authors: Miriam Bäumers; Sven Klose; Christian Brüser; Carl Haag; Sebastian Hänsch; Hendrik Pannen; Stefanie Weidtkamp-Peters; Michael Feldbrügge; Thomas Klein Journal: Biol Open Date: 2019-09-02 Impact factor: 2.422