Monika Pogorzala1, Jan Styczynski, Mariusz Wysocki. 1. Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, ul. Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland. jstyczynski@cm.umk.pl.
Abstract
AIM: Analysis of risk factors for survival in long-term follow-up of children treated at a single pediatric center in Poland. PATIENTS AND METHODS: Out of 623 children diagnosed with cancer between 1995-2005, 110 were treated for brain tumors and followed-up, with a mean survival of 11.4 years. RESULTS: Overall 5-year survival in the whole cohort was 60.9±4.7%, while 10-year survival was 58.2±4.7%. No relapse, progression or death occurred after six years from initial diagnosis. Survival was 48.1±9.6% for patients with medulloblastoma and primitive neuroectodermal tumors; 83.3±6.2% for low-grade astrocytoma; 56.6±16.6% for ependymoma, while 0% at 72 months for high-grade glioma. Patients with cerebellar tumors had a survival rate 69.0±7.1% at 10 years. Multivariate analysis showed that factors predicting poor outcome were: grade III-IV tumor, incomplete surgical resection, and complications after surgical resection, while diagnosis of low-grade glioma was the only factor predicting good outcome. Progression of the disease during therapy was an additional independent adverse risk factor for survival. CONCLUSION: Long-term survival was achieved by 58% of children with brain tumors. Advanced tumor stage, incomplete surgical resection, complications of surgical treatment, and progression of the disease during treatment predicted poor outcome.
AIM: Analysis of risk factors for survival in long-term follow-up of children treated at a single pediatric center in Poland. PATIENTS AND METHODS: Out of 623 children diagnosed with cancer between 1995-2005, 110 were treated for brain tumors and followed-up, with a mean survival of 11.4 years. RESULTS: Overall 5-year survival in the whole cohort was 60.9±4.7%, while 10-year survival was 58.2±4.7%. No relapse, progression or death occurred after six years from initial diagnosis. Survival was 48.1±9.6% for patients with medulloblastoma and primitive neuroectodermal tumors; 83.3±6.2% for low-grade astrocytoma; 56.6±16.6% for ependymoma, while 0% at 72 months for high-grade glioma. Patients with cerebellar tumors had a survival rate 69.0±7.1% at 10 years. Multivariate analysis showed that factors predicting poor outcome were: grade III-IV tumor, incomplete surgical resection, and complications after surgical resection, while diagnosis of low-grade glioma was the only factor predicting good outcome. Progression of the disease during therapy was an additional independent adverse risk factor for survival. CONCLUSION: Long-term survival was achieved by 58% of children with brain tumors. Advanced tumor stage, incomplete surgical resection, complications of surgical treatment, and progression of the disease during treatment predicted poor outcome.
Authors: Eduardo Javier Barragán-Pérez; Carlos Enrique Altamirano-Vergara; Daniel Eduardo Alvarez-Amado; Juan Carlos García-Beristain; Fernando Chico-Ponce-de-León; Vicente González-Carranza; Luis Juárez-Villegas; Chiharu Murata Journal: Pathol Oncol Res Date: 2020-07-13 Impact factor: 2.874
Authors: Dragana Stanić; Danica Grujičić; Tatjana Pekmezović; Jelena Bokun; Marija Popović-Vuković; Dragana Janić; Lejla Paripović; Vesna Ilić; Marija Pudrlja Slović; Rosanda Ilić; Savo Raičević; Milan Sarić; Ivana Mišković; Borko Nidžović; Marina Nikitović Journal: PLoS One Date: 2021-10-26 Impact factor: 3.240