Literature DB >> 2440284

Anaphylactoid reactions and histamine release do not occur after application of the opioid tramadol.

H Barth, H Giertz, A Schmal, W Lorenz.   

Abstract

After an i.v. application of 100 mg tramadol in 13 healthy volunteers no change in plasma histamine concentration could be detected,( systemic anaphylactoid reactions did not occur, cutaneous reactions were not rated as anaphylactoid since itching and erythema were seen only once after tramadol whereas erythema was also observed twice after saline, blood pressure and heart rate were only very slightly and transiently elevated without any abnormalities in ECG-readings and only side effects typical for opioid therapy were observed.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2440284     DOI： 10.1007/bf02074699

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

Review 1.  H1 and H2 blockade: a prophylactic principle in anesthesia and surgery against histamine-release responses of any degree of severity: Part 1.

Authors:  W Lorenz; A Doenicke
Journal:  N Engl Reg Allergy Proc       Date:  1985

2.  Definition and classification of the histamine-release response to drugs in anaesthesia and surgery: studies in the conscious human subject.

Authors:  W Lorenz; A Doenicke; B Schöning; C Ohmann; B Grote; E Neugebauer
Journal:  Klin Wochenschr       Date:  1982-09-01

3.  Histamine release with intravenous narcotics: protective effects of H1 and H2-receptor antagonists.

Authors:  D M Philbin; J Moss; C E Rosow; C W Akins; J L Rosenberger
Journal:  Klin Wochenschr       Date:  1982-09-01

4.  Intraspinal opiates and itching: a new reflex?

Authors:  P V Scott; H B Fischer
Journal:  Br Med J (Clin Res Ed)       Date:  1982-04-03

5.  Effect of the opioid analgesic tramadol on inactivation of norepinephrine and serotonin.

Authors:  H H Hennies; E Friderichs; K Wilsmann; L Floh e
Journal:  Biochem Pharmacol       Date:  1982-04-15       Impact factor: 5.858

Review 6.  Histamine release in clinical conditions.

Authors:  W Lorenz; A Doenicke
Journal:  Mt Sinai J Med       Date:  1978 May-Jun

7.  Immunological and non-immunological mechanisms involved in adverse reactions to drugs.

Authors:  J Watkins; J A Thornton
Journal:  Klin Wochenschr       Date:  1982-09-01

8.  A sensitive and specific method for the determination of histomine in human whole blood and plasma.

Authors:  W Lorenz; H J Reimann; H Barth; J Kusche; R Meyer; A Doenicke; M Hutzel
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1972-06

9.  [The behavior of plasma histamine levels following peridural morphine administration].

Authors:  S Berg-Seiter; B Kossmann; W Dick; W Lorenz
Journal:  Anaesthesist       Date:  1985-08       Impact factor: 1.041
  9 in total
  4 in total

Review 1.  Clinical pharmacology of tramadol.

Authors:  Stefan Grond; Armin Sablotzki
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

Review 2.  A risk-benefit assessment of tramadol in the management of pain.

Authors:  L Radbruch; S Grond; K A Lehmann
Journal:  Drug Saf       Date:  1996-07       Impact factor: 5.606

Review 3.  Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states.

Authors:  C R Lee; D McTavish; E M Sorkin
Journal:  Drugs       Date:  1993-08       Impact factor: 9.546

4.  The influence of tritoqualin (Inhibostamin) on the plasma histamine level and its biorhythmic variations.

Authors:  D Rehn; H J Reimann; M von der Ohe; U Schmidt; G Hennings
Journal:  Agents Actions       Date:  1987-12
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.