| Literature DB >> 2440281 |
Abstract
Antigen challenge of isolated perfused kidneys of sensitized guinea-pigs consistently released a large proportion of their histamine content, and caused a reduction in renal perfusate flow rate (RPFR) which could not simply be due to the released histamine, since much larger amounts of exogenous histamine were needed to produce a comparable effect. Reduction in RPFR by histamine was blocked by mepyramine but not by cimetidine, i.e. it is mediated by an H1-receptor mechanism.Entities:
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Year: 1987 PMID: 2440281 DOI: 10.1007/bf02074695
Source DB: PubMed Journal: Agents Actions ISSN: 0065-4299