Literature DB >> 2440263

Study of the inhibition of histamine release by inosine pranobex.

R Ziesche, D Eichelberg, W Schmutzler.   

Abstract

The effects of Inosine pranobex and its parent compounds inosine and dimethylamino-2-propanol-p-acetamidobenzoic acid (DipPacBa) on the Concanavalin A (ConA)-induced histamine release from human adenoidal mast cells were investigated. Inosine pranobex inhibited the ConA-induced histamine release at concentrations greater than 10(-3) M. Inosine itself (10(-5)-10(-2) M) enhanced the ConA-induced histamine release whereas DipPacBa inhibited the release significantly at concentrations between 10(-6) and 10(-2) M. These results are consistent with the assumption that the effect of Inosine pranobex is due to the DipPacBa moiety.

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Year:  1987        PMID： 2440263     DOI： 10.1007/bf02074660

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine.

Authors:  M A Beaven; S Jacobsen; Z Horáková
Journal:  Clin Chim Acta       Date:  1972-03       Impact factor: 3.786

2.  The human adenoidal mast cell. Susceptibility to different secretagogues and secretion inhibitors.

Authors:  W Schmutzler; K Delmich; D Eichelberg; S Glück; T Greven; H Jürgensen; K P Riesener; G Risse; P Pult
Journal:  Int Arch Allergy Appl Immunol       Date:  1985

3.  The effects of adenosine and of some adenosine analogues on the concanavalin A-or acetylcholine-induced histamine release from human adenoidal mast cells.

Authors:  K Delmich; D Eichelberg; W Schmutzler
Journal:  Agents Actions       Date:  1985-04

Review 4.  Inosiplex: an immunomodulation model for the treatment of viral disease.

Authors:  T Ginsberg; A J Glasky
Journal:  Ann N Y Acad Sci       Date:  1977-03-04       Impact factor: 5.691

5.  Isoprinosine as an immunopotentiator.

Authors:  G Renoux; M Renoux; J M Guillaumin
Journal:  J Immunopharmacol       Date:  1979

6.  Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation.

Authors:  J W Hadden; E M Hadden; R G Coffey
Journal:  Infect Immun       Date:  1976-02       Impact factor: 3.441
  6 in total

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