Literature DB >> 2440259

The role of intracellular Ca2+ in the degranulation of skinned mast cells.

K Tasaka, M Mio, M Okamoto.   

Abstract

The intracellular pH of rat peritoneal mast cells was slightly acidic and compound 48/80 induced a decrease in the cytoplasmic pH of these cells. By means of chemical skinning, it was revealed that perfusion with Ca2+ or inositol 1,4,5-trisphosphate (IP3) induced degranulation dose-dependently in mast cells at concentrations higher than 10 microM and 0.1 microM, respectively. Na+ was essential for the release of histamine from mast cells. An assay based on the binding of 45Ca to mast cell fragments revealed that the intracellular Ca store of the mast cell is located in the endoplasmic reticulum. IP3 liberated Ca from the endoplasmic reticulum.

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Year:  1987        PMID： 2440259     DOI： 10.1007/bf02074656

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Cation-induced histamine release from a synthetic weak (carboxylic) cation exchanger resin (IRC-50) and from isolated mast cell granules show identical kinetics.

Authors:  B Uvnäs
Journal:  Agents Actions       Date:  1985-04

2.  Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs.

Authors:  K Tasaka; M Mio; M Okamoto
Journal:  Ann Allergy       Date:  1986-06

3.  Changes in intracellular Ca2+ distribution of rat peritoneal mast cells before and after histamine release.

Authors:  K Tasaka; M Mio; M Okamoto
Journal:  Agents Actions       Date:  1986-04

4.  Mode of binding of histamine and some other biogenic amines to a protamine-heparin complex in vitro.

Authors:  C H Aborg; B Uvnäs
Journal:  Acta Physiol Scand       Date:  1968-12

5.  A high affinity calcium-stimulated magnesium-dependent adenosine triphosphatase in rat adipocyte plasma membranes.

Authors:  H A Pershadsingh; J M McDonald
Journal:  J Biol Chem       Date:  1980-05-10       Impact factor: 5.157

6.  Inhibitory effect of lysophosphatidylcholine on the histamine release from rat peritoneal mast cells.

Authors:  M Mio; A Ikeda; M Akagi; K Tasaka
Journal:  Agents Actions       Date:  1985-04

7.  Dual pathways for epidermal growth factor processing after receptor-mediated endocytosis.

Authors:  W K Miskimins; N Shimizu
Journal:  J Cell Physiol       Date:  1982-09       Impact factor: 6.384

8.  myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

Authors:  S K Joseph; A P Thomas; R J Williams; R F Irvine; J R Williamson
Journal:  J Biol Chem       Date:  1984-03-10       Impact factor: 5.157

9.  Analytical study of microsomes and isolated subcellular membranes from rat liver. I. Biochemical methods.

Authors:  H Beaufay; A Amar-Costesec; E Feytmans; D Thinès-Sempoux; M Wibo; M Robbi; J Berthet
Journal:  J Cell Biol       Date:  1974-04       Impact factor: 10.539

10.  Cytoplasmic pH and free Mg2+ in lymphocytes.

Authors:  T J Rink; R Y Tsien; T Pozzan
Journal:  J Cell Biol       Date:  1982-10       Impact factor: 10.539
  10 in total
  4 in total

1.  Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents.

Authors:  Chih-Chang Wei; Naoki Hase; Yukiko Inoue; Eddie W Bradley; Eiji Yahiro; Ming Li; Nawazish Naqvi; Pamela C Powell; Ke Shi; Yoshimasa Takahashi; Keijiro Saku; Hidenori Urata; Louis J Dell'italia; Ahsan Husain
Journal:  J Clin Invest       Date:  2010-03-24       Impact factor: 14.808

2.  Calcium- and guanine-nucleotide-dependent exocytosis in permeabilized rat mast cells. Modulation by protein kinase C.

Authors:  W R Koopmann; R C Jackson
Journal:  Biochem J       Date:  1990-01-15       Impact factor: 3.857

3.  Regulation of lymphocyte proliferation by eosinophils via chymotrypsin-like protease activity and adhesion molecule interaction.

Authors:  Y Matsunaga; M Shono; M Takahashi; Y Tsuboi; K Ogawa; T Yamada
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

4.  Dual regulation of the Na+/H(+)-exchange in rat peritoneal mast cells: role of protein kinase C and calcium on pHi regulation and histamine release.

Authors:  U G Friis; T Johansen
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739
  4 in total

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