Literature DB >> 24402325

Selective monomethylation of primary amines with simple electrophiles.

Thomas Lebleu1, Xiaolu Ma, Jacques Maddaluno, Julien Legros.   

Abstract

Direct monomethylation of primary amines with methyl triflate was achieved with high selectivity (up to 96%). The key point of this single methyl transfer stems from the use of HFIP as the solvent that interferes with amines and avoids overmethylation.

Entities:  

Year:  2014        PMID： 24402325     DOI： 10.1039/c3cc48997c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  A versatile way for the synthesis of monomethylamines by reduction of N-substituted carbonylimidazoles with the NaBH4/I2 system.

Authors:  Lin Chen; Xuan Zhou; Zhiyong Chen; Changxu Wang; Shunjie Wang; Hanbing Teng
Journal:  Beilstein J Org Chem       Date:  2022-08-17       Impact factor: 2.544

2.  Absorption, Fluorescence, and Two-Photon Excitation Ability of 5-Phenylisolidolo[2,1-a]quinolines.

Authors:  Ramon Francisco Avena; Lin Qiao; Yuki Fujii; Kohei Otomo; Hirokazu Ishii; Takeyuki Suzuki; Hirofumi Tsujino; Tadayuki Uno; Yasuo Tsutsumi; Yusuke Kawashima; Tatsuya Takagi; Kenichi Murai; Tomomi Nemoto; Mitsuhiro Arisawa
Journal:  ACS Omega       Date:  2020-01-27
  2 in total

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