INTRODUCTION: The incidence of delayed graft function (DGF) and unsatisfactory creatinine clearance (UCC) after renal transplantation is significantly higher in Brazil, when compared with that observed in United States or Europe. Deceased donor (DD) characteristics should directly influence the occurrence of these two outcomes. OBJECTIVE: This study aim to evaluate the influence of DD characteristics on DGF and UCC incidence in Brazil. METHODS: DD clinical and laboratory variables were correlated with outcome's incidence. RESULTS: We evaluated 787 DD whose organs were transplanted in 1298 patients. We noted a high prevalence of vasoactive drugs use (90.2%), hypernatremia (66.6%) and renal dysfunction (34.8%). The incidence of DGF and UCC was 60.6% and 55.2%, respectively. We observed a progressive increase in DGF risk for age groups over 30 years and for cold ischemia time (CIT) greater than 24 hours. DGF risk was two times higher in recipients of donor kidney final serum creatinine (Cr) over than 1.5 mg/dl. Hypertension and CIT over 36 hours was associated with an increasing of 82% and 99% in UCC risk, respectively. Donor age above 40 years was associated with a progressive increase in UCC risk. CONCLUSION: DD age, renal function, hypertension and prolonged CIT were associated with increased risk DGF and UCC.
INTRODUCTION: The incidence of delayed graft function (DGF) and unsatisfactory creatinine clearance (UCC) after renal transplantation is significantly higher in Brazil, when compared with that observed in United States or Europe. Deceased donor (DD) characteristics should directly influence the occurrence of these two outcomes. OBJECTIVE: This study aim to evaluate the influence of DD characteristics on DGF and UCC incidence in Brazil. METHODS: DD clinical and laboratory variables were correlated with outcome's incidence. RESULTS: We evaluated 787 DD whose organs were transplanted in 1298 patients. We noted a high prevalence of vasoactive drugs use (90.2%), hypernatremia (66.6%) and renal dysfunction (34.8%). The incidence of DGF and UCC was 60.6% and 55.2%, respectively. We observed a progressive increase in DGF risk for age groups over 30 years and for cold ischemia time (CIT) greater than 24 hours. DGF risk was two times higher in recipients of donor kidney final serum creatinine (Cr) over than 1.5 mg/dl. Hypertension and CIT over 36 hours was associated with an increasing of 82% and 99% in UCC risk, respectively. Donor age above 40 years was associated with a progressive increase in UCC risk. CONCLUSION: DD age, renal function, hypertension and prolonged CIT were associated with increased risk DGF and UCC.
Authors: João Batista Saldanha De Castro Filho; Jeferson De Castro Pompeo; Rafael Berlezi Machado; Luiz Felipe Santos Gonçalves; Andrea Carla Bauer; Roberto Ceratti Manfro Journal: Transpl Int Date: 2022-03-24 Impact factor: 3.782
Authors: Helio Tedesco-Silva; Juliano Chrystian Mello Offerni; Vanessa Ayres Carneiro; Mayara Ivani de Paula; Elias David Neto; Francine Brambate Carvalhinho Lemos; Lúcio Roberto Requião Moura; Alvaro Pacheco E Silva Filho; Mirian de Fátima de Morais Cunha; Erica Francisco da Silva; Luiz Antonio Miorin; Daniela Priscila Demetrio; Paulo Sérgio Luconi; Waldere Tania da Silva Luconi; Savina Adriana Bobbio; Liz Milstein Kuschnaroff; Irene Lourdes Noronha; Sibele Lessa Braga; Renata Cristina Barsante; João Cezar Mendes Moreira; Ida Maria Maximina Fernandes-Charpiot; Mario Abbud-Filho; Luis Gustavo Modelli de Andrade; Paula Dalsoglio Garcia; Luciana Tanajura Santamaria Saber; Alan Fernandes Laurindo; Pedro Renato Chocair; Américo Lourenço Cuvello Neto; Juliana Aparecida Zanocco; Antonio Jose Duboc de Almeida Soares Filho; Wilson Ferreira Aguiar; Jose Medina Pestana Journal: Transplant Direct Date: 2017-04-18