Collagen fleece failed to prevent intrapleural adhesions in a canine model: failure of murine models to translate into a large animal model.

Intrapleural and anti-adhesive materials were investigated in murine models, but not in a large animal model before clinical application. Our results failed to show any anti-adhesion effect of collagen fleece and suggested the thoracic physiology in murine models would not translate into a large animal model.