BACKGROUND: Infants with critical congenital heart disease who require cardiothoracic surgical intervention may have significant post-operative mortality and morbidity. Infants who are small for gestational age <10th percentile with foetal growth restriction may have end-organ dysfunction that may predispose them to increased morbidity or mortality. METHODS: A single-institution retrospective review was performed in 230 infants with congenital heart disease who had cardiothoracic surgical intervention <60 days of age. Pre-, peri-, and post-operative morbidity and mortality markers were collected along with demographics and anthropometric measurements. RESULTS: There were 230 infants, 57 (23.3%) small for gestational age and 173 (70.6%) appropriate for gestational age. No significant difference was noted in pre-operative markers - gestational age, age at surgery, corrected gestational age, Society for Thoracic Surgeons and European Association for Cardiothoracic Surgery mortality score; or post-operative factors - length of stay, ventilation days, arrhythmias, need for extracorporeal membrane oxygenation, vocal cord dysfunction, hearing loss; or end-organ dysfunction - gastro-intestinal, renal, central nervous system, or genetic. Small for gestational age infants were more likely to have failed vision tests (p = 0.006). Small for gestational age infants were more likely to have increased 30-day (p = 0.005) and discharge mortality (p = 0.035). Small for gestational age infants with normal birth weight (>2500 g) were also at increased risk of 30-day mortality compared with appropriate for gestational age infants (p = 0.045). CONCLUSIONS: Small for gestational age infants with congenital heart disease who undergo cardiothoracic surgery <60 days of age have increased risk of mortality and failed vision screening. Assessment of foetal growth restriction as part of routine pre-operative screening may be beneficial.
BACKGROUND:Infants with critical congenital heart disease who require cardiothoracic surgical intervention may have significant post-operative mortality and morbidity. Infants who are small for gestational age <10th percentile with foetal growth restriction may have end-organ dysfunction that may predispose them to increased morbidity or mortality. METHODS: A single-institution retrospective review was performed in 230 infants with congenital heart disease who had cardiothoracic surgical intervention <60 days of age. Pre-, peri-, and post-operative morbidity and mortality markers were collected along with demographics and anthropometric measurements. RESULTS: There were 230 infants, 57 (23.3%) small for gestational age and 173 (70.6%) appropriate for gestational age. No significant difference was noted in pre-operative markers - gestational age, age at surgery, corrected gestational age, Society for Thoracic Surgeons and European Association for Cardiothoracic Surgery mortality score; or post-operative factors - length of stay, ventilation days, arrhythmias, need for extracorporeal membrane oxygenation, vocal cord dysfunction, hearing loss; or end-organ dysfunction - gastro-intestinal, renal, central nervous system, or genetic. Small for gestational age infants were more likely to have failed vision tests (p = 0.006). Small for gestational age infants were more likely to have increased 30-day (p = 0.005) and discharge mortality (p = 0.035). Small for gestational age infants with normal birth weight (>2500 g) were also at increased risk of 30-day mortality compared with appropriate for gestational age infants (p = 0.045). CONCLUSIONS: Small for gestational age infants with congenital heart disease who undergo cardiothoracic surgery <60 days of age have increased risk of mortality and failed vision screening. Assessment of foetal growth restriction as part of routine pre-operative screening may be beneficial.
Authors: Faith Ross; Gregory Latham; Denise Joffe; Michael Richards; Jeremy Geiduschek; Michael Eisses; Douglas Thompson; Monique Radman Journal: Cardiol Young Date: 2017-06-19 Impact factor: 1.093
Authors: Jill J Savla; Mary E Putt; Jing Huang; Samuel Parry; Julie S Moldenhauer; Samantha Reilly; Olivia Youman; Jack Rychik; Laura Mercer-Rosa; J William Gaynor; Steven M Kawut Journal: J Am Heart Assoc Date: 2022-01-11 Impact factor: 6.106
Authors: Ali Ghanchi; Neil Derridj; Damien Bonnet; Nathalie Bertille; Laurent J Salomon; Babak Khoshnood Journal: Int J Environ Res Public Health Date: 2020-04-28 Impact factor: 3.390
Authors: Carey Yun Shan Lim; Joel Kian Boon Lim; Rajesh Babu Moorakonda; Chengsi Ong; Yee Hui Mok; John Carson Allen; Judith Ju-Ming Wong; Teng Hong Tan; Jan Hau Lee Journal: Front Pediatr Date: 2019-10-23 Impact factor: 3.418
Authors: Martina A Steurer; Rebecca J Baer; Edmund Burke; Shabnam Peyvandi; Scott Oltman; Christina D Chambers; Mary E Norton; Larry Rand; Satish Rajagopal; Kelli K Ryckman; Sky K Feuer; Liang Liang; Randi A Paynter; Molly McCarthy; Anita J Moon-Grady; Roberta L Keller; Laura L Jelliffe-Pawlowski Journal: J Am Heart Assoc Date: 2018-09-04 Impact factor: 5.501