Literature DB >> 24400731

5-hydroxymethylcytosine-mediated DNA demethylation in stem cells and development.

Wenjia Sun1, Minxin Guan, Xuekun Li.   

Abstract

The pursuit of DNA demethylation has a colorful history, but it was not until 2009 that the stars of this story, the Ten-eleven-translocation (Tet) family of proteins, were really identified. Tet proteins convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which can be further oxidized to 5-formylcytosine and 5-cyboxycytosine by Tet proteins to achieve DNA demethylation. Recent studies have revealed that 5hmC-mediated DNA demethylation can play essential roles in diverse biological processes, including development and diseases. Here, we review recent discoveries in 5hmC-mediated DNA demethylation in the context of stem cells and development.

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Year:  2014        PMID： 24400731     DOI： 10.1089/scd.2013.0428

Source DB:  PubMed          Journal:  Stem Cells Dev        ISSN： 1547-3287            Impact factor:   3.272


  13 in total

1.  Neuroepigenomics: Resources, Obstacles, and Opportunities.

Authors:  John S Satterlee; Andrea Beckel-Mitchener; Roger Little; Dena Procaccini; Joni L Rutter; Amy C Lossie
Journal:  Neuroepigenetics       Date:  2015-01-01

2.  5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme.

Authors:  Fabio Ciccarone; Elisabetta Valentini; Michele Zampieri; Paola Caiafa
Journal:  Oncotarget       Date:  2015-09-15

3.  Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells.

Authors:  Estela G Toraño; Gustavo F Bayón; Álvaro Del Real; Marta I Sierra; María G García; Antonella Carella; Thalia Belmonte; Rocío G Urdinguio; Isabel Cubillo; Javier García-Castro; Jesús Delgado-Calle; Flor M Pérez-Campo; José A Riancho; Mario F Fraga; Agustín F Fernández
Journal:  J Transl Med       Date:  2016-07-08       Impact factor: 5.531

Review 4.  Environmentally induced epigenetic toxicity: potential public health concerns.

Authors:  Emma L Marczylo; Miriam N Jacobs; Timothy W Gant
Journal:  Crit Rev Toxicol       Date:  2016-06-09       Impact factor: 5.635

Review 5.  Deciphering the Epigenetic Code in Embryonic and Dental Pulp Stem Cells.

Authors:  Dashzeveg Bayarsaihan
Journal:  Yale J Biol Med       Date:  2016-12-23

6.  TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors.

Authors:  Pierre-Benoit Ancey; Szilvia Ecsedi; Marie-Pierre Lambert; Fazlur Rahman Talukdar; Marie-Pierre Cros; Denise Glaise; Diana Maria Narvaez; Veronique Chauvet; Zdenko Herceg; Anne Corlu; Hector Hernandez-Vargas
Journal:  Stem Cell Reports       Date:  2017-06-22       Impact factor: 7.765

7.  Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.

Authors:  Miriam Landfors; Jostein Johansen; Jan Magnus Aronsen; Cathrine Broberg Vågbø; Louis C Doré; Chuan He; Ivar Sjaastad; Pål Sætrom; Péter Fedorcsák; John Arne Dahl; Håvard Aanes; Markus Fußer; Arne Klungland
Journal:  Cell Discov       Date:  2017-05-09       Impact factor: 10.849

8.  Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma.

Authors:  Sama Ahsan; Eric H Raabe; Michael C Haffner; Ajay Vaghasia; Katherine E Warren; Martha Quezado; Leomar Y Ballester; Javad Nazarian; Charles G Eberhart; Fausto J Rodriguez
Journal:  Acta Neuropathol Commun       Date:  2014-06-03       Impact factor: 7.801

9.  Hypo-hydroxymethylation of rRNA genes in the precocious Eriocheir sinensis testes revealed using hMeDIP-seq.

Authors:  Genliang Li; Hui Qian
Journal:  Sci Rep       Date:  2017-09-11       Impact factor: 4.379

10.  The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation.

Authors:  Huikang Tao; Pei Xie; Yuhang Cao; Liqi Shu; Liping Li; Junchen Chen; Guangfeng Tian; Yingliang Zhuang; Qiang Shu; Xuekun Li
Journal:  Stem Cells Int       Date:  2018-03-11       Impact factor: 5.443
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