Literature DB >> 2439901

Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange.

S Hattori, D J Clanton, T Satoh, S Nakamura, Y Kaziro, M Kawakita, T Y Shih.   

Abstract

The neutralizing monoclonal antibody Y13-259 severely hampers the nucleotide exchange reaction between p21-bound and exogenous guanine nucleotides but does not interfere with the association of GDP to p21. These results suggest that the nucleotide exchange reaction is critical for p21 function. Interestingly, the v-ras p21 has a much faster dissociation rate than the p21 of the c-ras proto-oncogene.

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Year:  1987        PMID： 2439901      PMCID： PMC365309          DOI： 10.1128/mcb.7.5.1999-2002.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  27 in total

1.  Monoclonal antibody Y13-259 recognizes an epitope of the p21 ras molecule not directly involved in the GTP-binding activity of the protein.

Authors:  J C Lacal; S A Aaronson
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

2.  Mutational analysis of a ras catalytic domain.

Authors:  B M Willumsen; A G Papageorge; H F Kung; E Bekesi; T Robins; M Johnsen; W C Vass; D R Lowy
Journal:  Mol Cell Biol       Date:  1986-07       Impact factor: 4.272

Review 3.  The role of guanosine 5'-triphosphate in polypeptide chain elongation.

Authors:  Y Kaziro
Journal:  Biochim Biophys Acta       Date:  1978-09-21

4.  The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras.

Authors:  A Hall; A J Self
Journal:  J Biol Chem       Date:  1986-08-25       Impact factor: 5.157

5.  Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.

Authors:  D J Capon; E Y Chen; A D Levinson; P H Seeburg; D V Goeddel
Journal:  Nature       Date:  1983-03-03       Impact factor: 49.962

6.  G proteins and dual control of adenylate cyclase.

Authors:  A G Gilman
Journal:  Cell       Date:  1984-03       Impact factor: 41.582

7.  Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.

Authors:  E Taparowsky; Y Suard; O Fasano; K Shimizu; M Goldfarb; M Wigler
Journal:  Nature       Date:  1982-12-23       Impact factor: 49.962

8.  Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus.

Authors:  T Y Shih; A G Papageorge; P E Stokes; M O Weeks; E M Scolnick
Journal:  Nature       Date:  1980-10-23       Impact factor: 49.962

9.  Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family.

Authors:  M E Furth; L J Davis; B Fleurdelys; E M Scolnick
Journal:  J Virol       Date:  1982-07       Impact factor: 5.103

10.  High-level expression in Escherichia coli of enzymatically active Harvey murine sarcoma virus p21ras protein.

Authors:  J A Lautenberger; L Ulsh; T Y Shih; T S Papas
Journal:  Science       Date:  1983-08-26       Impact factor: 47.728
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  18 in total

1.  GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sites.

Authors:  A Valencia; M Kjeldgaard; E F Pai; C Sander
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

2.  Modulation of maturation and ribosomal protein S6 phosphorylation in Xenopus oocytes by microinjection of oncogenic ras protein and protein kinase C.

Authors:  T Kamata; H F Kung
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

Review 3.  The biochemistry of ras p21.

Authors:  R J Grand; D Owen
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

4.  Antibodies to synthetic peptide from the residue 33 to 42 domain of c-Ha-ras p21 block reconstitution of the protein with different effectors.

Authors:  I Rey; P Soubigou; L Debussche; C David; A Morgat; P E Bost; J F Mayaux; B Tocque
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

5.  H-ras mutants lacking the epitope for the neutralizing monoclonal antibody Y13-259 show decreased biological activity and are deficient in GTPase-activating protein interaction.

Authors:  S K Srivastava; A Di Donato; J C Lacal
Journal:  Mol Cell Biol       Date:  1989-04       Impact factor: 4.272

Review 6.  Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.

Authors:  Jonathan M L Ostrem; Kevan M Shokat
Journal:  Nat Rev Drug Discov       Date:  2016-07-29       Impact factor: 84.694

7.  Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts.

Authors:  J S Scheele; J M Rhee; G R Boss
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-14       Impact factor: 11.205

8.  Activation of the mitogen-activated protein kinase pathway in Triton X-100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells.

Authors:  P Dent; J Wu; G Romero; L A Vincent; D Castle; T W Sturgill
Journal:  Mol Biol Cell       Date:  1993-05       Impact factor: 4.138

9.  Structural significance of the GTP-binding domain of ras p21 studied by site-directed mutagenesis.

Authors:  D J Clanton; Y Y Lu; D G Blair; T Y Shih
Journal:  Mol Cell Biol       Date:  1987-09       Impact factor: 4.272

10.  Ceramide inhibits inwardly rectifying K+ currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes.

Authors:  H Hida; M Takeda; B Soliven
Journal:  J Neurosci       Date:  1998-11-01       Impact factor: 6.167
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