Roberto Scilletta1, Duilio Pagano2, Marco Spada2, Sebastiano Mongiovì3, Antonio Pesce4, Teresa R Portale4, Vincenzo Guardabasso5, Stefano Puleo4, Salvatore Gruttadauria2. 1. Department of Surgical Sciences, University of Catania, Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy. Electronic address: robertoscilletta@gmail.com. 2. Department of Surgery, University of Pittsburgh, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center in Italy, Palermo, Italy. 3. Department of Abdominal Oncology Surgery, Humanitas Centro Catanese di Oncologia, Catania, Italy. 4. Department of Surgical Sciences, University of Catania, Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy. 5. Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy.
Abstract
BACKGROUND: The aim of this study was to identify the incidence of surgical site infections (SSIs) and postoperative complications, as defined by the Clavien-Dindo classification, after hepatic resection for metastatic colorectal cancer in patients with and without associated neoadjuvant chemotherapy. METHODS: A total of 181 patients were studied retrospectively. Patients were divided into two groups: the first group comprised patients with associated neoadjuvant chemotherapeutic treatment for liver metastases with a latency time <8 wk and the second group comprised patients without associated neoadjuvant chemotherapy. RESULTS: Variables of duration of liver surgery, length of total hospital stay, and length of postoperative hospital stay seem to be correlated with SSIs and postoperative complications, P < 0.005 and P < 0.0001, respectively. Duration of surgery is a risk factor for SSIs, with an odds ratio of 1.15, and for complications according to the Clavien-Dindo classification, with an odds ratio of 1.35. CONCLUSIONS: Neoadjuvant chemotherapy was not a significant risk factor for SSIs, whereas the total length of hospital stay, length of postoperative hospital stay, and duration of surgery were independent predictors of SSIs and complications according to the Clavien-Dindo classification.
BACKGROUND: The aim of this study was to identify the incidence of surgical site infections (SSIs) and postoperative complications, as defined by the Clavien-Dindo classification, after hepatic resection for metastatic colorectal cancer in patients with and without associated neoadjuvant chemotherapy. METHODS: A total of 181 patients were studied retrospectively. Patients were divided into two groups: the first group comprised patients with associated neoadjuvant chemotherapeutic treatment for liver metastases with a latency time <8 wk and the second group comprised patients without associated neoadjuvant chemotherapy. RESULTS: Variables of duration of liver surgery, length of total hospital stay, and length of postoperative hospital stay seem to be correlated with SSIs and postoperative complications, P < 0.005 and P < 0.0001, respectively. Duration of surgery is a risk factor for SSIs, with an odds ratio of 1.15, and for complications according to the Clavien-Dindo classification, with an odds ratio of 1.35. CONCLUSIONS: Neoadjuvant chemotherapy was not a significant risk factor for SSIs, whereas the total length of hospital stay, length of postoperative hospital stay, and duration of surgery were independent predictors of SSIs and complications according to the Clavien-Dindo classification.