S Joshi1, J M Babu2, D Jayalakshmi2, V Kulkarni3, U Divate4, R Muwonge5, T Gheit6, M Tommasino6, R Sankaranarayanan7, M R Pillai2. 1. Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital Premises, 32 Sassoon Road, Pune 411001, India; Prayas Health Group, Amrita Clinic, Athwale Corner, Karve Road, Deccan Gymkhana, Pune, India. 2. Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram 695014, Kerala, India. 3. Prayas Health Group, Amrita Clinic, Athwale Corner, Karve Road, Deccan Gymkhana, Pune, India. 4. Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital Premises, 32 Sassoon Road, Pune 411001, India. 5. Screening Group (SCR), Early Detection & Prevention Section (EDP), International Agency for Research on Cancer (WHO-IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. 6. Infections and Cancer Biology Group, Infections Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. 7. Screening Group (SCR), Early Detection & Prevention Section (EDP), International Agency for Research on Cancer (WHO-IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France. Electronic address: sankarr@iarc.fr.
Abstract
INTRODUCTION: Frequency and distribution of HPV types in HIV-infected women with and without cervical neoplasia and their determinants have not been widely studied in India. We report and discuss HPV prevalence and type distribution in HIV-infected women. METHODS: HPV genotyping was done using cervical samples from 1109 HIV-infected women in a cross-sectional study. RESULTS: Any HPV was detected in 44.8% and high-risk ones in 41.0% women. Frequency of single and multiple high-risk infections were 26.7% and 14.3%, respectively. Frequencies of high-risk HPV infections in women with and without cervical neoplasia were 73.5% and 37.6%, respectively. HPV16 was the most common genotype, present in 11.5%, and 58.5% of women with cervical intraepithelial neoplasia (CIN) 2 and 3. Other most common high-risk HPV types in CIN 2-3 lesions were HPV 31 (22.6%); 56 (13.2%); 18 and 68a (11.3%) and 33, 35 and 51 (9.4%); and 70 (7.5%). Women under 30 or over 44 years, no abortions, and women with diagnosis of HIV infection within the last 5 years were at high risk of multiple oncogenic HPV infection. CONCLUSION: We observed a very high frequency of high-risk HPV and multiple infections in HIV-infected women.
INTRODUCTION: Frequency and distribution of HPV types in HIV-infected women with and without cervical neoplasia and their determinants have not been widely studied in India. We report and discuss HPV prevalence and type distribution in HIV-infected women. METHODS: HPV genotyping was done using cervical samples from 1109 HIV-infected women in a cross-sectional study. RESULTS: Any HPV was detected in 44.8% and high-risk ones in 41.0% women. Frequency of single and multiple high-risk infections were 26.7% and 14.3%, respectively. Frequencies of high-risk HPV infections in women with and without cervical neoplasia were 73.5% and 37.6%, respectively. HPV16 was the most common genotype, present in 11.5%, and 58.5% of women with cervical intraepithelial neoplasia (CIN) 2 and 3. Other most common high-risk HPV types in CIN 2-3 lesions were HPV 31 (22.6%); 56 (13.2%); 18 and 68a (11.3%) and 33, 35 and 51 (9.4%); and 70 (7.5%). Women under 30 or over 44 years, no abortions, and women with diagnosis of HIV infection within the last 5 years were at high risk of multiple oncogenic HPV infection. CONCLUSION: We observed a very high frequency of high-risk HPV and multiple infections in HIV-infected women.
Authors: L Stewart Massad; Xianhong Xie; Robert D Burk; Gypsyamber D'Souza; Teresa M Darragh; Howard Minkoff; Christine Colie; Pamela Burian; Joel Palefsky; Jessica Atrio; Howard D Strickler Journal: Am J Obstet Gynecol Date: 2015-11-14 Impact factor: 8.661
Authors: Chandrika J Piyathilake; Suguna Badiga; Greer A Burkholder; Shuko Harada; James L Raper Journal: Cancer Med Date: 2021-02-19 Impact factor: 4.452
Authors: S Joshi; A Mane; R Muwonge; U Divate; V Padbidri; V Kulkarni; R Gangakhedkar; R Sankaranarayanan Journal: Int J STD AIDS Date: 2020-03-31 Impact factor: 1.359
Authors: Rakiya Saidu; Louise Kuhn; Ana Tergas; Rosalind Boa; Jennifer Moodley; Cecilia Svanholm-Barrie; David Persing; Scott Campbell; Wei-Yann Tsai; Thomas C Wright; Lynette Denny Journal: J Low Genit Tract Dis Date: 2021-01-01 Impact factor: 3.842