Literature DB >> 24397780

Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95.

Rachel A Daut1, Erica F Busch, Jessica Ihne, Daniel Fisher, Masayoshi Mishina, Seth G N Grant, Marguerite Camp, Andrew Holmes.   

Abstract

The neural and genetic factors underlying chronic tolerance to alcohol are currently unclear. The GluN2A N-methyl-D-aspartate receptors (NMDAR) subunit and the NMDAR-anchoring protein PSD-95 mediate acute alcohol intoxication and represent putative mechanisms mediating tolerance. We found that chronic intermittent ethanol exposure (CIE) did not produce tolerance [loss of righting reflex (LORR)] or withdrawal-anxiety in C57BL/6J, GluN2A or PSD-95 knockout mice assayed 2-3 days later. However, significant tolerance to LORR was evident 1 day after CIE in C57BL/6J and PSD-95 knockouts, but absent in GluN2A knockouts. These data suggest a role for GluN2A in tolerance, extending evidence that human GluN2A gene variation is involved in alcohol dependence.
© 2014 Society for the Study of Addiction.

Entities:  

Keywords:  GluN2A and PSD-95; chronic ethanol; tolerance

Mesh：

Substances：

Year:  2014        PMID： 24397780      PMCID： PMC4085154          DOI： 10.1111/adb.12110

Source DB:  PubMed          Journal:  Addict Biol        ISSN： 1355-6215            Impact factor:   4.280


  13 in total

1.  Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome.

Authors:  Michael Feyder; Rose-Marie Karlsson; Poonam Mathur; Matthew Lyman; Roland Bock; Reza Momenan; Jeeva Munasinghe; Maria Luisa Scattoni; Jessica Ihne; Marguerite Camp; Carolyn Graybeal; Douglas Strathdee; Alison Begg; Veronica A Alvarez; Peter Kirsch; Marcella Rietschel; Sven Cichon; Henrik Walter; Andreas Meyer-Lindenberg; Seth G N Grant; Andrew Holmes
Journal:  Am J Psychiatry       Date:  2010-10-15       Impact factor: 18.112

2.  Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice.

Authors:  Marcelo F Lopez; William C Griffin; Roberto I Melendez; Howard C Becker
Journal:  Alcohol Clin Exp Res       Date:  2012-02-06       Impact factor: 3.455

3.  Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.

Authors:  Lauren Debrouse; Benita Hurd; Carly Kiselycznyk; Aaron Plitt; Alyssa Todaro; Masayoshi Mishina; Seth G N Grant; Marguerite Camp; Ozge Gunduz-Cinar; Andrew Holmes
Journal:  Alcohol Clin Exp Res       Date:  2012-08-30       Impact factor: 3.455

4.  Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit.

Authors:  Janel M Boyce-Rustay; Andrew Holmes
Journal:  Psychopharmacology (Berl)       Date:  2006-07-12       Impact factor: 4.530

5.  Withdrawal severity after chronic intermittent ethanol in inbred mouse strains.

Authors:  Pamela Metten; Michelle L Sorensen; Andy J Cameron; Chia-Hua Yu; John C Crabbe
Journal:  Alcohol Clin Exp Res       Date:  2010-06-25       Impact factor: 3.455

6.  A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference.

Authors:  Marguerite C Camp; Michael Feyder; Jessica Ihne; Benjamin Palachick; Benita Hurd; Rose-Marie Karlsson; Bianca Noronha; Yi-Chyan Chen; Marcelo P Coba; Seth G N Grant; Andrew Holmes
Journal:  Addict Biol       Date:  2011-02-11       Impact factor: 4.280

7.  Long-lasting tolerance to alcohol following a history of dependence.

Authors:  Roberto Rimondini; Wolfang H Sommer; Rossella Dall'Olio; Markus Heilig
Journal:  Addict Biol       Date:  2008-03       Impact factor: 4.280

8.  Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.

Authors:  Gunter Schumann; Monika Johann; Josef Frank; Ulrich Preuss; Norbert Dahmen; Manfred Laucht; Marcella Rietschel; Dan Rujescu; Anbarasu Lourdusamy; Toni-Kim Clarke; Kristina Krause; Anne Dyer; Martin Depner; Stefan Wellek; Jens Treutlein; Armin Szegedi; Ina Giegling; Sven Cichon; Dorothea Blomeyer; Andreas Heinz; Simon Heath; Mark Lathrop; Norbert Wodarz; Michael Soyka; Rainer Spanagel; Karl Mann
Journal:  Arch Gen Psychiatry       Date:  2008-07

9.  Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding.

Authors:  Andrew Holmes; Paul J Fitzgerald; Kathryn P MacPherson; Lauren DeBrouse; Giovanni Colacicco; Shaun M Flynn; Sophie Masneuf; Kristen E Pleil; Chia Li; Catherine A Marcinkiewcz; Thomas L Kash; Ozge Gunduz-Cinar; Marguerite Camp
Journal:  Nat Neurosci       Date:  2012-09-02       Impact factor: 24.884

10.  Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.

Authors:  Yi-Chyan Chen; Andrew Holmes
Journal:  Neuropsychopharmacology       Date:  2008-10-08       Impact factor: 7.853
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  13 in total

1.  Chronic Ethanol During Adolescence Impacts Corticolimbic Dendritic Spines and Behavior.

Authors:  Nicholas J Jury; Gabrielle A Pollack; Meredith J Ward; Jessica L Bezek; Alexandra J Ng; Courtney R Pinard; Hadley C Bergstrom; Andrew Holmes
Journal:  Alcohol Clin Exp Res       Date:  2017-06-14       Impact factor: 3.455

2.  NMDA receptor GluN2A subunit deletion protects against dependence-like ethanol drinking.

Authors:  Nicholas J Jury; Anna K Radke; Dipanwita Pati; Adrina Kocharian; Masayoshi Mishina; Thomas L Kash; Andrew Holmes
Journal:  Behav Brain Res       Date:  2018-06-25       Impact factor: 3.332

3.  Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID).

Authors:  Robert Hitzemann; Denesa Oberbeck; Ovidiu Iancu; Priscila Darakjian; Shannon McWeeney; Stephanie Spence; Jason Schlumbohm; Pamela Metten; John Crabbe
Journal:  Alcohol       Date:  2017-04-12       Impact factor: 2.405

4.  Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking.

Authors:  Katherine M Holleran; Hadley H Wilson; Tracy L Fetterly; Rebecca J Bluett; Samuel W Centanni; Rachel A Gilfarb; Lauren E R Rocco; Sachin Patel; Danny G Winder
Journal:  Neuropsychopharmacology       Date:  2016-01-11       Impact factor: 7.853

5.  The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal-Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins.

Authors:  Jonathan H Lindsay; Rebecca A Prosser
Journal:  Alcohol Clin Exp Res       Date:  2017-12-27       Impact factor: 3.455

6.  Chronic EtOH effects on putative measures of compulsive behavior in mice.

Authors:  Anna K Radke; Nicholas J Jury; Adrina Kocharian; Catherine A Marcinkiewcz; Emily G Lowery-Gionta; Kristen E Pleil; Zoe A McElligott; Jessica M McKlveen; Thomas L Kash; Andrew Holmes
Journal:  Addict Biol       Date:  2015-12-21       Impact factor: 4.280

7.  NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism.

Authors:  Carly Kiselycznyk; Nicholas J Jury; Lindsay R Halladay; Kazu Nakazawa; Masayoshi Mishina; Rolf Sprengel; Seth G N Grant; Per Svenningsson; Andrew Holmes
Journal:  Behav Brain Res       Date:  2015-03-21       Impact factor: 3.332

8.  Sex differences in the behavioral sequelae of chronic ethanol exposure.

Authors:  Nicholas J Jury; Jeffrey F DiBerto; Thomas L Kash; Andrew Holmes
Journal:  Alcohol       Date:  2016-08-18       Impact factor: 2.405

9.  The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits.

Authors:  Paula A Zamudio; Dominic A Gioia; Marcelo Lopez; Gregg E Homanics; John J Woodward
Journal:  Psychopharmacology (Berl)       Date:  2020-10-14       Impact factor: 4.530

Review 10.  Tolerance to alcohol: A critical yet understudied factor in alcohol addiction.

Authors:  Sophie K Elvig; M Adrienne McGinn; Caroline Smith; Michael A Arends; George F Koob; Leandro F Vendruscolo
Journal:  Pharmacol Biochem Behav       Date:  2021-02-23       Impact factor: 3.533
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