Literature DB >> 2439707

Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus.

J W Gnann, J A Nelson, M B Oldstone.   

Abstract

Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.

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Year:  1987        PMID： 2439707      PMCID： PMC255715     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2).

Authors:  R Sanchez-Pescador; M D Power; P J Barr; K S Steimer; M M Stempien; S L Brown-Shimer; W W Gee; A Renard; A Randolph; J A Levy
Journal:  Science       Date:  1985-02-01       Impact factor: 47.728

2.  AIDS in Africa: an epidemiologic paradigm.

Authors:  T C Quinn; J M Mann; J W Curran; P Piot
Journal:  Science       Date:  1986-11-21       Impact factor: 47.728

Review 3.  Solid-phase peptide synthesis.

Authors:  R B Merrifield
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1969

4.  Human pituitary growth hormone. XVI. Reduction with dithiothreitol in the absence of urea.

Authors:  T A Bewley; J S Dixon; C H Li
Journal:  Biochim Biophys Acta       Date:  1968-02-19

5.  Prediction of protein antigenic determinants from amino acid sequences.

Authors:  T P Hopp; K R Woods
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

Review 6.  Antibodies of predetermined specificity in biology and medicine.

Authors:  R A Lerner
Journal:  Adv Immunol       Date:  1984       Impact factor: 3.543

7.  Antibodies that react with predetermined sites on proteins.

Authors:  J G Sutcliffe; T M Shinnick; N Green; R A Lerner
Journal:  Science       Date:  1983-02-11       Impact factor: 47.728

8.  Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

Authors:  F Barré-Sinoussi; J C Chermann; F Rey; M T Nugeyre; S Chamaret; J Gruest; C Dauguet; C Axler-Blin; F Vézinet-Brun; C Rouzioux; W Rozenbaum; L Montagnier
Journal:  Science       Date:  1983-05-20       Impact factor: 47.728

9.  Computer-assisted analysis of envelope protein sequences of seven human immunodeficiency virus isolates: prediction of antigenic epitopes in conserved and variable regions.

Authors:  S Modrow; B H Hahn; G M Shaw; R C Gallo; F Wong-Staal; H Wolf
Journal:  J Virol       Date:  1987-02       Impact factor: 5.103

10.  Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.

Authors:  R C Gallo; S Z Salahuddin; M Popovic; G M Shearer; M Kaplan; B F Haynes; T J Palker; R Redfield; J Oleske; B Safai
Journal:  Science       Date:  1984-05-04       Impact factor: 47.728
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  83 in total

1.  Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus challenge in Macaques.

Authors:  P S Polacino; V Stallard; J E Klaniecki; S Pennathur; D C Montefiori; A J Langlois; B A Richardson; W R Morton; R E Benveniste; S L Hu
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein.

Authors:  A L Edinger; M Ahuja; T Sung; K C Baxter; B Haggarty; R W Doms; J A Hoxie
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

3.  Binding antibody responses to the immunogenic regions of viral envelope in HIV-1-infected Indian children.

Authors:  S S Prakash; Raiees Andrabi; Rajesh Kumar; S K Kabra; Rakesh Lodha; Madhu Vajpayee; Kalpana Luthra
Journal:  Viral Immunol       Date:  2011-12       Impact factor: 2.257

4.  Examination of sera from human immunodeficiency virus type 1 (HIV-1)-infected individuals for antibodies reactive with peptides corresponding to the principal neutralizing determinant of HIV-1 gp120 and for in vitro neutralizing activity.

Authors:  R Q Warren; S A Anderson; W M Nkya; J F Shao; C W Hendrix; G P Melcher; R R Redfield; R C Kennedy
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

5.  Neutralizing antibodies and antigens in AIDS.

Authors:  S G Norley; R Kurth
Journal:  Infection       Date:  1991       Impact factor: 3.553

6.  Two immunodominant domains of gp41 bind antibodies which enhance human immunodeficiency virus type 1 infection in vitro.

Authors:  W E Robinson; M K Gorny; J Y Xu; W M Mitchell; S Zolla-Pazner
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

7.  B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus.

Authors:  R D Schrier; J W Gnann; A J Langlois; K Shriver; J A Nelson; M B Oldstone
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

8.  Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies.

Authors:  B Pfeiffer; Z N Berneman; F Neipel; C K Chang; S Tirwatnapong; B Chandran
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

9.  Synthetic peptides representing sequences within gp41 of HIV as immunogens for murine T- and B-cell responses.

Authors:  L E Brown; D O White; C Agius; B E Kemp; N Yatzakis; P Poumbourios; D A McPhee; D C Jackson
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

10.  Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus env proteins possess a functionally conserved assembly domain.

Authors:  R W Doms; P L Earl; S Chakrabarti; B Moss
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103
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