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Literature DB >> 24395388

Applications of miRNA technology for atherosclerosis.

Hiroe Toba¹, Dolores Cortez, Merry L Lindsey, Robert J Chilton.

Abstract

MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers
MicroRNAs

Year: 2014 PMID： 24395388 PMCID： PMC4362664 DOI： 10.1007/s11883-013-0386-9

Source DB: PubMed Journal: Curr Atheroscler Rep ISSN： 1523-3804 Impact factor: 5.113

20 in total

1. Circulating microRNAs in patients with coronary artery disease.

Authors: Stephan Fichtlscherer; Salvatore De Rosa; Henrik Fox; Thomas Schwietz; Ariane Fischer; Christoph Liebetrau; Michael Weber; Christian W Hamm; Tino Röxe; Marga Müller-Ardogan; Angelika Bonauer; Andreas M Zeiher; Stefanie Dimmeler
Journal: Circ Res Date: 2010-07-01 Impact factor: 17.367

2. Primary prevention of cardiovascular disease with a Mediterranean diet.

Authors: Ramón Estruch; Emilio Ros; Jordi Salas-Salvadó; Maria-Isabel Covas; Dolores Corella; Fernando Arós; Enrique Gómez-Gracia; Valentina Ruiz-Gutiérrez; Miquel Fiol; José Lapetra; Rosa Maria Lamuela-Raventos; Lluís Serra-Majem; Xavier Pintó; Josep Basora; Miguel Angel Muñoz; José V Sorlí; José Alfredo Martínez; Miguel Angel Martínez-González
Journal: N Engl J Med Date: 2013-02-25 Impact factor: 91.245

3. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b.

Authors: Dongliang Wang; Min Xia; Xiao Yan; Dan Li; Lei Wang; Yuxuan Xu; Tianru Jin; Wenhua Ling
Journal: Circ Res Date: 2012-07-19 Impact factor: 17.367

4. A functional polymorphism at miR-491-5p binding site in the 3'-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population.

Authors: Mei Yuan; Qiong Zhan; Xiaomei Duan; Bingxin Song; Sian Zeng; Xiaoping Chen; Qidong Yang; Jian Xia
Journal: Atherosclerosis Date: 2012-12-08 Impact factor: 5.162

5. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

Authors: W H Wilson Tang; Zeneng Wang; Bruce S Levison; Robert A Koeth; Earl B Britt; Xiaoming Fu; Yuping Wu; Stanley L Hazen
Journal: N Engl J Med Date: 2013-04-25 Impact factor: 91.245

6. Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.

Authors: Li Ma; Jing Yang; H Birali Runesha; Toshiko Tanaka; Luigi Ferrucci; Stefania Bandinelli; Yang Da
Journal: BMC Med Genet Date: 2010-04-06 Impact factor: 2.103

7. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Authors: R C Lee; R L Feinbaum; V Ambros
Journal: Cell Date: 1993-12-03 Impact factor: 41.582

8. Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes.

Authors: B M Herrera; H E Lockstone; J M Taylor; M Ria; A Barrett; S Collins; P Kaisaki; K Argoud; C Fernandez; M E Travers; J P Grew; J C Randall; A L Gloyn; D Gauguier; M I McCarthy; C M Lindgren
Journal: Diabetologia Date: 2010-03-03 Impact factor: 10.122

9. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.

Authors: Takahiro Horie; Osamu Baba; Yasuhide Kuwabara; Yoshimasa Chujo; Shin Watanabe; Minako Kinoshita; Masahito Horiguchi; Tomoyuki Nakamura; Kazuhisa Chonabayashi; Masakatsu Hishizawa; Koji Hasegawa; Noriaki Kume; Masayuki Yokode; Toru Kita; Takeshi Kimura; Koh Ono
Journal: J Am Heart Assoc Date: 2012-12-19 Impact factor: 5.501

10. Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α.

Authors: A Meerson; M Traurig; V Ossowski; J M Fleming; M Mullins; L J Baier
Journal: Diabetologia Date: 2013-06-12 Impact factor: 10.122

13 in total

1. Evaluation of miR-29c inhibits endotheliocyte migration and angiogenesis of human endothelial cells by suppressing the insulin like growth factor 1.

Authors: Yun Hu; Feng Deng; Jinlin Song; Juhong Lin; Xue Li; Yuying Tang; Jie Zhou; Tian Tang; Leilei Zheng
Journal: Am J Transl Res Date: 2015-03-15 Impact factor: 4.060

2. Evaluation of miR-29c inhibits endotheliocyte migration and angiogenesis of human endothelial cells by suppressing the insulin like growth factor 1.

Authors: Yun Hu; Feng Deng; Jinlin Song; Juhong Lin; Xue Li; Yuying Tang; Jie Zhou; Tian Tang; Leilei Zheng
Journal: Am J Transl Res Date: 2015-05-15 Impact factor: 4.060

3. Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis.

Authors: Beiyun Wang; Yuan Zhong; Dong Huang; Jingbo Li
Journal: Am J Transl Res Date: 2016-02-15 Impact factor: 4.060

Applications of miRNA technology for atherosclerosis.

1. Circulating microRNAs in patients with coronary artery disease.

2. Primary prevention of cardiovascular disease with a Mediterranean diet.

3. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b.

4. A functional polymorphism at miR-491-5p binding site in the 3'-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population.

5. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

6. Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.

7. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

8. Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes.

9. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.

10. Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α.

1. Evaluation of miR-29c inhibits endotheliocyte migration and angiogenesis of human endothelial cells by suppressing the insulin like growth factor 1.

2. Evaluation of miR-29c inhibits endotheliocyte migration and angiogenesis of human endothelial cells by suppressing the insulin like growth factor 1.

3. Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis.

4. MiR-129-5p-mediated Beclin-1 suppression inhibits endothelial cell autophagy in atherosclerosis.

5. Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis.

Review 6. The regulatory role of microRNAs in angiogenesis-related diseases.

7. PPAR𝛾 Gene and Atherosclerosis: Genetic Polymorphisms, Epigenetics and Therapeutic Implications.

8. BMSCs and miR-124a ameliorated diabetic nephropathy via inhibiting notch signalling pathway.

Review 9. Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling.

10. Expression status and clinical significance of lncRNA APPAT in the progression of atherosclerosis.