Literature DB >> 24395238

In vitro efficacy of a novel active-release antimicrobial coating to eradicate biofilms of Pseudomonas aeruginosa.

Dustin L Williams1, Julia M Lerdahl, Bryan S Haymond, Roy D Bloebaum.   

Abstract

Implant-related infections are becoming increasingly difficult to treat due to the formation of biofilms on implant surfaces. This study analyzed the in vitro efficacy of a novel antimicrobial coating against biofilms of Pseudomonas aeruginosa, using a flow cell system. Results indicated that P. aeruginosa biofilms were reduced by greater than 8 log10 units in less than 24 h. Data indicated that this active-release coating may be promising for preventing biofilm implant-related infections.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24395238      PMCID： PMC4023794          DOI： 10.1128/AAC.01798-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  45 in total

Review 1.  Multidrug-resistant bacteria: overcoming antibiotic permeability barriers of gram-negative bacteria.

Authors:  P B Savage
Journal:  Ann Med       Date:  2001-04       Impact factor: 4.709

Review 2.  Bacterial biofilms: a common cause of persistent infections.

Authors:  J W Costerton; P S Stewart; E P Greenberg
Journal:  Science       Date:  1999-05-21       Impact factor: 47.728

Review 3.  Biofilm theory can guide the treatment of device-related orthopaedic infections.

Authors:  J William Costerton
Journal:  Clin Orthop Relat Res       Date:  2005-08       Impact factor: 4.176

Review 4.  Antibiotic-eluting medical devices for various applications.

Authors:  Meital Zilberman; Jonathan J Elsner
Journal:  J Control Release       Date:  2008-08-06       Impact factor: 9.776

Review 5.  Reducing implant-related infections: active release strategies.

Authors:  Evan M Hetrick; Mark H Schoenfisch
Journal:  Chem Soc Rev       Date:  2006-05-05       Impact factor: 54.564

6.  Effect on infection resistance of a local antiseptic and antibiotic coating on osteosynthesis implants: an in vitro and in vivo study.

Authors:  Thomas Kälicke; Jörg Schierholz; Urs Schlegel; Thomas Manfred Frangen; Manfred Köller; Gert Printzen; Dominik Seybold; Stefan Klöckner; Gert Muhr; Stephan Arens
Journal:  J Orthop Res       Date:  2006-08       Impact factor: 3.494

7.  Experimental model of biofilm implant-related osteomyelitis to test combination biomaterials using biofilms as initial inocula.

Authors:  Dustin L Williams; Bryan S Haymond; Kassie L Woodbury; J Peter Beck; David E Moore; R Tyler Epperson; Roy D Bloebaum
Journal:  J Biomed Mater Res A       Date:  2012-04-10       Impact factor: 4.396

8.  Treatment of osteomyelitis in rats by injection of degradable polymer releasing gentamicin.

Authors:  Yaron S Brin; Jacob Golenser; Boaz Mizrahi; Guy Maoz; Abraham J Domb; Shyamal Peddada; Shmuel Tuvia; Abraham Nyska; Meir Nyska
Journal:  J Control Release       Date:  2008-07-20       Impact factor: 9.776

9.  Anti-infective efficacy of antiseptic-coated intramedullary nails.

Authors:  R O Darouiche; J Farmer; C Chaput; M Mansouri; G Saleh; G C Landon
Journal:  J Bone Joint Surg Am       Date:  1998-09       Impact factor: 5.284

10.  The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study.

Authors:  Thomas Fuchs; Richard Stange; Gerhard Schmidmaier; Michael J Raschke
Journal:  Arch Orthop Trauma Surg       Date:  2011-05-24       Impact factor: 3.067
View more
  3 in total

1.  Biofilm Growth on Simulated Fracture Fixation Plates Using a Customized CDC Biofilm Reactor for a Sheep Model of Biofilm-Related Infection.

Authors:  Walker Kay; Connor Hunt; Lisa Nehring; Brian Barnum; Nicholas Ashton; Dustin Williams
Journal:  Microorganisms       Date:  2022-03-31

2.  Growth substrate may influence biofilm susceptibility to antibiotics.

Authors:  Dustin L Williams; Scott R Smith; Brittany R Peterson; Gina Allyn; Lousili Cadenas; Richard Tyler Epperson; Ryan E Looper
Journal:  PLoS One       Date:  2019-03-14       Impact factor: 3.240

Review 3.  An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence.

Authors:  Charles D Morin; Eric Déziel; Jeff Gauthier; Roger C Levesque; Gee W Lau
Journal:  Virulence       Date:  2021-12       Impact factor: 5.882
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.