Jianming Huang1, Leimin Qian. 1. Department of Gastroenterological Surgery, Jiangyin People's Hospital, Jiangyin, Jiangsu Province, China, 214400, qqllmm2003@163.com.
Abstract
OBJECTIVE: This study was intended to evaluate the efficacy of fibrin glue (FG) in preventing post-traumatic focal pancreatitis (PTFP) after radical gastrectomy by examining the drainage fluids over 7 days post-op. METHODS:Ninety-five patients who underwent D2 radical gastrectomy for gastric cancer were randomly assigned to a fibrin glue group (n = 48) receiving fibrin glue on the raw surface of the pancreas during surgery and a control group (n = 47), which did not receive fibrin glue. RESULTS: We found no significant difference in operation time and intraoperative blood loss between groups (p > 0.05); no deaths occurred during surgery. The volume of ascitic fluid containing blood cells in the fibrin glue group was significantly lower than that in the control group (p < 0.001) at all times observed. Amylase levels in the drained fluids were highest at 24 h postoperatively in both groups, suggesting pancreatitis, but gradually decreased to normal levels within 7 days. The amylase in the drains in the control group was significantly higher than that in the FG group (p < 0.001) at all times observed, but it returned to normal 72 h postoperatively in the FG group. One death by hemorrhagic shock associated with PTFP was recorded in the control group. CONCLUSION:Fibrin glue is safe and effective in preventing PTFP following gastric surgery and shortens the clinical course of the disease.
RCT Entities:
OBJECTIVE: This study was intended to evaluate the efficacy of fibrin glue (FG) in preventing post-traumatic focal pancreatitis (PTFP) after radical gastrectomy by examining the drainage fluids over 7 days post-op. METHODS: Ninety-five patients who underwent D2 radical gastrectomy for gastric cancer were randomly assigned to a fibrin glue group (n = 48) receiving fibrin glue on the raw surface of the pancreas during surgery and a control group (n = 47), which did not receive fibrin glue. RESULTS: We found no significant difference in operation time and intraoperative blood loss between groups (p > 0.05); no deaths occurred during surgery. The volume of ascitic fluid containing blood cells in the fibrin glue group was significantly lower than that in the control group (p < 0.001) at all times observed. Amylase levels in the drained fluids were highest at 24 h postoperatively in both groups, suggesting pancreatitis, but gradually decreased to normal levels within 7 days. The amylase in the drains in the control group was significantly higher than that in the FG group (p < 0.001) at all times observed, but it returned to normal 72 h postoperatively in the FG group. One death by hemorrhagic shock associated with PTFP was recorded in the control group. CONCLUSION: Fibrin glue is safe and effective in preventing PTFP following gastric surgery and shortens the clinical course of the disease.
Authors: W Testi; C Staffieri; R Malatesti; Y Macchitella; A De Martino; G Botta; D Cirianni; A Genovese; C Bing; M Logatt Journal: Minerva Chir Date: 2007-02 Impact factor: 1.000
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