John P Corcoran1, Najib M Rahman2. 1. Oxford Centre for Respiratory Medicine, Oxford University Hospitals, Oxford, England; Oxford Respiratory Trials Unit, University of Oxford, Oxford, England. 2. Oxford Centre for Respiratory Medicine, Oxford University Hospitals, Oxford, England; Oxford Respiratory Trials Unit, University of Oxford, Oxford, England; NIHR Oxford Biomedical Research Centre, Oxford, England. Electronic address: najib.rahman@ndm.ox.ac.uk.